 | | Vol. 12.46 – 3 December, 2021 |
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| Scientists generated a comprehensive prostate cancer transcriptome atlas that described the roadmap to tumor progression in a qualitative and quantitative manner. Using patient-derived xenograft models, they functionally validated their observations and added single-cell resolution.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that endothelial-to-osteoblast transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer cells.
[Oncogene] |
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| The effect of PTEN on prostate cancer cell migration, apoptosis and the cell cycle was analyzed in vitro using a wound healing assay and flow cytometry.
[Molecular Therapy-Nucleic Acids] |
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| A large-scale immunohistochemical analysis of ten–eleven translocation methylcytosine dioxygenase 1 (TET1) was performed in normal prostate and prostate cancer using conventional slides and tissue microarrays.
[Clinical Epigenetics] |
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| Scientists noted that heterogeneous nuclear ribonucleoprotein K (HnRNPK) emerged as an important player in the carcinogenesis process of prostate cancer (PrCa). miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3’-UTR in PrCa cell lines in which HnRNPK was overexpressed.
[Cancer Cell International] |
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| Researchers characterized and investigated the effects of transient receptor potential melastatin-8 (TRPM8) modulators in prostate cancer aggressiveness disclosing the molecular mechanism underlying their biological activity.
[Scientific Reports] |
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| Physachenolide C is a 17β-hydroxywithanolide natural product with a unique anticancer potential, as it exhibited potent and selective in vitro antiproliferative activity against prostate cancer (PC) cells. Investigators explored the effect of ring A/B modifications of physachenolide C on biological activities.
[Journal of Natural Products] |
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| Scientists investigated the involvement of the SDF-1/CXCR4 axis in the process of bone marrow mesenchymal stem cells (BMMSC) homing in prostate cancer (PCa) in vivo and in vitro and suggested that BMMSCs could home and promote the proliferation and migration of PCa through the SDF-1/CXCR4 axis.
[Clinical and Translational Oncology] |
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| Curmumin (CRN)-NLC nanoparticles were administrated to nude mice with LNCaP prostate cancer xenografts and demonstrated substantial tumor volume suppression with no weight loss compared to pure CRN.
[Drug Delivery and Translational Research] |
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| Investigators showed that hsa_circ_0030586 was significantly upregulated in prostate cancer (PCa) cells. Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion.
[Bioengineered] |
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| Scientists discuss prostate cancer (PCa) from the perspective of an abnormal organ development and deregulated cellular differentiation, and discuss the luminal progenitor cells as the likely cells of origin for PCa.
[Seminars in Cancer Biology] |
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| Investigators synthesize all the available data for seminal fluid biomarkers used to assess patients with chronic prostatitis/chronic pelvic pain syndrome. Inflammatory seminal biomarkers were the most frequently studied, with IL6, IL8, TNFα and IL1β being the most promising candidates
[Prostate Cancer and Prostatic Diseases] |
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| The authors question the role of metagenomics studies in the diagnosis and treatment of prostate cancer (PC). Based on next-generation sequencing-generated data, Proteobacteria, Firmicutes, Actinobacteria, and Bacteriodetes are the nine frequent phyla detected in a PC sample.
[Prostate] |
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| The Phase III ARASENS trial investigating the use of the oral androgen receptor inhibitor darolutamide in metastatic hormone-sensitive prostate cancer, darolutamide in combination with docetaxel and androgen deprivation therapy (ADT) significantly increased overall survival compared to placebo, docetaxel and ADT.
[Orion Corporation] |
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| January 9 – 12, 2022
Portland, Oregon, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | University of Freiburg – Freiburg, Germany |
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| | Lund University РMalm̦, Sweden |
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