 | | Vol. 12.48 – 17 December, 2021 |
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| Researchers sequenced the accessible chromatin regions of 14,424 single-cells from 18 flash-frozen prostate tumors and observed shared chromatin features among low-grade prostate cancer cells were lost in high-grade tumors.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated an intricate balance between androgen receptor and MYC, and indicated that increased MYC in response to androgen deprivation contributed to CRPC, while decreased MYC may contribute to responses to supraphysiological androgen therapy.
[Nature Communications] |
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| Utilizing the CWR22 xenograft model, scientists demonstrated that stably reduced NCOR2 expression accelerated disease recurrence following androgen deprivation therapy, associated with gene expression patterns that included neuroendocrine features, and induced DNA hypermethylation.
[Cell Reports] |
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| Expression of circular RNA derived from dipeptidyl peptidase 4 (circDPP4) was upregulated in prostate cancer (PC) tumors from 60 patients and PC cell lines, and higher circDPP4 might predict poor overall survival.
[Journal of Gene Medicine] |
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| Through an integration analysis of clinical genomic and transcriptomic profiles of prostate cancer (PC) tumors, investigators identified UBR5 as a top PC-relevant E3 ubiquitin ligase whose expression levels were strongly associated with PC progression and aggressiveness.
[Proteomics] |
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| Researchers found that prostate cancer cells appeared to retain their responsiveness to stromal proenkephalin (PENK) signaling. PENK could induce differentiation to counter de-differentiation caused by stem cell transcription factor activation.
[BMC Cancer] |
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| Investigators used prostate cancer cell line PC3 and its paclitaxel-resistant counterpart PC3-TxR as a cell model and suggested that lovastatin (LV) might increase the sensitivity of resistant prostate cancer cells to paclitaxel through inhibition of CYP2C8.
[Biochemical and Biophysical Research Communications] |
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| The authors explored the function and mechanism of LINC00184 in docetaxel resistance of prostate cancer and found that LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulting in upregulation of the expression of PD-L1.
[Immunobiology] |
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| Researchers investigated the role of miR-145-5p in prostate cancer (PCa) and its potential molecular mechanisms and confirmed that miR-145-5p inhibited the growth and metastasis of PCa cells by inhibiting the expression of proto-oncogene WIP1.
[Journal of Oncology] |
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| The authors focus on the investigations, prospects, and challenges associated with integrating engineering sciences with cancer biology to develop nanotechnology-based tools for prostate cancer diagnosis.
[Microchimica Acta] |
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| Veru, Inc. announced that the US FDA has approved ENTADFITM for the treatment of urinary tract symptoms caused by an enlarged prostate called benign prostatic hyperplasia.
[Veru, Inc.] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| | Pfizer – Collegeville, Pennsylvania, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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