 | | Vol. 13.00 – 7 January, 2022 |
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| Hsa_circ_0003258 physically bound to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activated the ERK signaling pathway and finally accelerated the metastasis of prostate cancer.
[Molecular Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed the expression profiles of circRNAs in docetaxel-resistant and -sensitive prostate cancer cells through RNA sequencing and found that expression of circARHGAP29 was significantly upregulated in docetaxel-resistant cell lines and clinical samples.
[Cancer Research] |
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| Investigators showed that ablation of type I fibroblast growth factor receptor (FGFR1) in DU145 human prostate cancer cells changed the cell metabolite profile. Among the changes, the choline metabolism profile was the most significantly altered by FGFR1 ablation.
[International Journal of Cancer] |
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| The potential synergistic anticancer effect and the underlying mechanisms of roburic acid in combination with docetaxel on prostate cancer were investigated.
[Journal of Enzyme inhibition and Medicinal Chemistry] |
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| Using human cell lines that represent androgen-independent or -sensitive prostate cancer, the authors showed that Mitochondrial Rho GTPase 2 (MIRO2) depletion impaired cell growth, colony formation, and tumor growth in mice.
[Molecular Cancer Research] |
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| High serum CD44 levels may have helped identify docetaxel-resistant patients and may have thereby helped optimize clinical decision-making regarding the type and timing of therapy for metastatic CRPC patients.
[Journal of Cellular and Molecular Medicine] |
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| Prostate cancer cells were differentiated with interleukin-6 (IL-6) in vitro to identify novel targets or signaling pathways associated with emergence of neuroendocrine prostate cancer on deprivation of androgens.
[Cellular Signalling] |
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| Researchers investigated the high level of EIF3J‐AS1 in prostate cancer (PCa) tissues and cells, and used functional assays to show that knocking down EIF3J‐AS1 inhibited PCa cell proliferation and metastatic ability.
[Journal of Cancer] |
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| Investigators demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of prostate cancer cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks than radiation alone in LNCaP cells.
[Radiation Research] |
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| Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.
[Bioengineered] |
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| The association of obesity with biochemical recurrence (BCR) after treatment of clinically localized prostate cancer shows inconsistent results. Investigators systematically review all evidence evaluating obesity as a prognostic factor for BCR.
[Prostate Cancer and Prostatic Diseases] |
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| The authors carried out an extensive literature search for the different biomarkers available for screening and diagnosis of prostate cancer and compared their performance with serum prostate specific antigen to allow clinicians to draw meaningful conclusions to offer their patients more personalized medical care.
[World Journal of Mens Health] |
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| Accutar Biotechnology, Inc. announced that the US FDA has cleared the company’s investigational new drug application (IND) for AC0176 for the treatment of patients with metastatic CRPC.
[Accutar Biotechnology, Inc.] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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