Prostate Cell News Volume 13.01 | Jan 14 2022

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    Justin.choi
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    2022-01-14 | PCN 13.01


    Prostate Cell News by STEMCELL Technologies
    Vol. 13.01 – 14 January, 2022
    TOP STORY

    Single-Cell Analysis of Human Primary Prostate Cancer Reveals the Heterogeneity of Tumor-Associated Epithelial Cell States

    Researchers uncovered heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that were enriched in prostate cancer and identified a population of tumor-associated club cells that may be associated with prostate carcinogenesis.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Overcoming Resistance to Immune Checkpoint Therapy in PTEN-Null Prostate Cancer by Intermittent Anti-PI3Kα/β/δ Treatment

    Scientists found that intermittent but not daily dosing of a PI3Kα/β/δ inhibitor, BAY1082439, on Pten-null prostate cancer models could overcome immune checkpoint therapy resistance and unleash CD8+ T cell-dependent anti-tumor immunity in vivo.
    [Nature Communications]

    Full Article

    MiR-423-5p Prevents MALAT1-Mediated Proliferation and Metastasis in Prostate Cancer

    Using lentiviral stable miRNA transfection together with cell biology functional assays and gene expression/target analysis, the authors investigated the interaction between MALAT1 and miR-423-5p, defined as a target with in silico prediction analysis, in prostate cancer.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Endoplasmic Reticulum Stress Inhibits AR Expression via the PERK/eIF2α/ATF4 Pathway in Luminal Androgen Receptor Triple-Negative Breast Cancer and Prostate Cancer

    Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor triple-negative breast cancer and prostate cancer.
    [npj Breast Cancer]

    Full Article

    Targeting Protein Arginine Methyltransferase 5 (PRMT5) Suppresses Radiation-Induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation

    Scientists performed transcriptomic analysis and confirmed that fractionated ionizing radiation (FIR)-induced neuroendocrine (NE)-like cells share some features of clinical NE prostate cancer, suggesting that FIR-induced NE differentiation represents a clinically-relevant model.
    [Molecular Cancer therapeutics]

    Abstract

    Combined Effect of Heat Shock Protein Inhibitor Geldanamycin and Free Radicals on Photodynamic Therapy of Prostate Cancer

    The authors found that the inhibition of Hsp90 could inhibit the overexpression of its client proteins such as anti-apoptotic proteins and androgen receptor, thereby improving the efficacy of photodynamic therapy and inducing prostate cancer cell apoptosis.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

    Investigators demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.
    [Molecular Cancer Research]

    AbstractFull Article

    Acquired Resistance to Irradiation or Docetaxel Is Not Associated with Cross-Resistance to Cisplatin in Prostate Cancer Cell Lines

    Researchers investigated whether acquired resistance against ionizing radiation or docetaxel chemotherapy—two commonly applied treatment modalities in prostate cancer—influenced the cisplatin tolerance in metastatic CRPC cell line models.
    [Journal of Cancer Research and Clinical Oncology]

    Full Article

    The Androgen Receptor Inhibits Transcription of GPER1 by Preventing Sp1 and Sp3 from Binding to the Promoters in Prostate Cancer Cells

    Scientists indicated that androgen receptor repressed transcription of GPER1 by binding to Sp1 and Sp3 independently to prevent their transactivation of the GPER1 promoters.
    [Oncotargets and Therapy]

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    REVIEWS

    Nutritional and Surgical Aspects in Prostate Disorders

    In order to understand why and how nutrition can be beneficial in diseases of the prostate, scientists give an overview of the known characteristics and features of this organ and propose nutrition-based treatment on prostate problems.
    [Critical Reviews in Food Science and Nutrition]

    Abstract

    INDUSTRY AND POLICY NEWS

    23andMe Receives FDA Clearance for Direct-to-Consumer Genetic Test on a Hereditary Prostate Cancer Marker

    23andMe Holding Co. received FDA clearance for a genetic health risk report on a hereditary prostate cancer marker.
    [23andMe Holding Co.]

    Press Release
    FEATURED EVENT

    Virtual Symposium on Urinary Extracellular Vesicles

    February 15-16, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Targeted Therapy

    University of Maryland, Baltimore – Baltimore, Maryland, United States

    Postdoctoral Research Fellow – Genetic Alterations in Prostate Cancer

    Wayne State University School of Medicine – Detroit, Michigan, United States

    Postdoctoral Position – Physiologic and Molecular Mechanisms

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Investigator – Cancer Biology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Professorship – Genitourinary Cancer

    University of California Irvine – Irvine, California, United States

    > See All Jobs

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