 | | Vol. 13.04 – 4 February, 2022 |
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| Scientists showed RIPK2 was a clinically actionable target for inhibiting prostate cancer (PC) metastasis. RIPK2 was amplified/gained in ~65% of lethal metastatic castration-resistant PC.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified the up-regulation of prostate-specific membrane antigen (PSMA)-like aminopeptidase NAALADaseL and the metabotropic glutamate receptors in PSMA-suppressed prostate cancers.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers demonstrated that retinoblastoma (Rb) family proteins played a central role in maintaining the global chromatin binding and transcriptional repression program of androgen receptor, and that Rb inactivation desensitized CRPC to the high-dose testosterone treatment in vitro and in vivo.
[Molecular Therapy] |
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| Investigators performed functional and synthetic lethal screens in four prostate cancer cell lines which confirmed key roles for HSP70, HSP90, and their co-chaperones, and suggested that the mitochondrial chaperone, HSP60/HSPD1, was selectively required in CRPC cell lines.
[Cell Chemical Biology] |
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| Scientists investigated the effect of PMD-026 on YB-1/AR signaling and its antitumor effect in prostate cancer in vitro and in vivo and demonstrated an excellent antitumor effect of the novel ribosomal S6 kinase inhibitor PMD-026 and the combination effect with the antiandrogen enzalutamide in CRPC.
[Cancer Science] |
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| Researchers found that combining p110β with RAC/PAK1 or tankyrase inhibitors significantly reduced the growth of murine and human CRPC organoids in vitro and in vivo.
[Molecular Cancer Research] |
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| Investigators compared the transcriptomes of nine canine cell lines derived from prostate adenocarcinoma (PAC), PAC metastasis and transitional cell carcinoma to their respective original primary tumor or metastasis tissues.
[Cancer Cell International] |
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| The authors explored the effect of the upregulation or downregulation of the NPM1 protein on the malignancy of prostate cancer and its possible signaling pathway.
[Clinical and Experimental Pharmacology and Physiology] |
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| Researchers demonstrated that SU086 inhibited the growth of prostate cancer cells in vitro, cell-line, and patient-derived xenografts in vivo, and ex vivo prostate cancer patient specimens.
[Cell Reports Medicine] |
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| Various mechanisms of resistance have been identified including the development of androgen receptor-independent aggressive variant prostate cancer based on neuroendocrine transdifferentiation (NED). Scientists review the highly complex processes contributing to NED.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors discuss androgen deprivation therapy (ADT) history, use of leuprolide, degarelix, and relugolix, with contextual use of ADT in combination with androgen-signaling inhibitors and potential mechanisms of resistance.
[Expert Opinion on Pharmacotherapy] |
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| LAVA Therapeutics announced dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-1207 in patients with metastatic CRPC.
[LAVA Therapeutics] |
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| Ultimovacs announced it has completed treatment of the second dose cohort in the Phase I TENDU trial. The study is designed to evaluate the company’s tetanus-epitope targeting-platform in patients with prostate cancer.
[Ultimovacs] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Cleveland Clinic Lerner Research Institute – Cleveland, Ohio, United States |
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| | Henry M. Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States |
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| | University of Maryland, Baltimore – Baltimore, Maryland, United States |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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