Prostate Cell News Volume 13.05 | Feb 11 2022

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    2022-02-11 | PCN 13.05


    Prostate Cell News by STEMCELL Technologies
    Vol. 13.05 – 11 February, 2022
    TOP STORY

    Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer

    Researchers described a mechanism by which CAF-secreted lactate was able to increase the expression of genes involved in lipid metabolism in prostate cancer cells.
    [Cancer Research]

    Abstract
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Plasticity within Aldehyde Dehydrogenase-Positive Cells Determines Prostate Cancer Radiosensitivity

    Scientists analyzed irradiation-induced plasticity within the aldehyde dehydrogenase-positive population in prostate cancer.
    [Molecular Cancer Research]

    Abstract

    P2Y1 Agonist HIC in Combination with Androgen Receptor Inhibitor Abiraterone Acetate Impairs Cell Growth of Prostate Cancer

    Researchers evaluated the combinatorial effect of HIC with abiraterone acetate targeted on androgen receptor on the inhibition of prostate cancer cells.
    [Apoptosis]

    Full Article

    δ-Tocotrienol Is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp-/- Mice

    The authors demonstrated that δ-tocotrienol effectively inhibited the development of prostate adenocarcinoma in Ptenp-/- mice, which involved inhibition of proliferation and angiogenesis and promotion of apoptosis.
    [Cancer Prevention Research]

    Abstract

    SNHG3 Could Promote Prostate Cancer Progression through Reducing Methionine Dependence of PCa Cells

    SNHG3 as a molecular sponge of miR-152-3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of prostate cancer (PCa) cells via targeting SLC7A11.
    [Cellular & Molecular Biology Letters]

    Full Article

    Autophagy Deficiency Promotes Lung Metastasis of Prostate Cancer via Stabilization of TWIST1

    The authors revealed ATG5-mediated autophagy was a key mechanism that controlled the metastasis of prostate cancer by regulating p62 abundance and TWIST1 stabilization.
    [Clinical and Translational Oncology]

    Abstract

    Design, Synthesis, and Characterization of PROTACs Targeting the Androgen Receptor in Prostate and Lung Cancer Model

    Scientists provided novel androgen receptor (AR)-directed proteolysis-targeting chimeras (PROTACs) and a clear rationale for further investigating AR involvement in lung cancer models.
    [Archiv Der Pharmazie]

    Full Article

    Mannose Inhibits the Growth of Prostate Cancer through a Mitochondrial Mechanism

    Researchers demonstrated that mannose inhibited the proliferation and promoted the apoptosis of prostate cancer cells in vitro, and mannose was observed to have an anticancer effect in mice without harming their health.
    [Asian Journal of andrology]

    Full Article

    Silencing of TP73-AS1 Impairs Prostate Cancer Cell Proliferation and Induces Apoptosis via Regulation of TP73

    Investigators provided novel evidence that suggests a chief regulatory role for the TP73-TP73-AS1 axis in prostate cancer development and progression, suggesting that the TP73/TP73-AS1 axis could be a promising diagnostic and therapeutic target for prostate cancer.
    [Molecular Biology Reports]

    Abstract

    Fibroblast Activation Protein-Alpha Knockdown Suppresses Prostate Cancer Cell Invasion and Proliferation

    Real-time quantitative PCR was used to detect the relative expression of fibroblast activation protein alpha mRNA in prostate cancer cell lines and human normal prostate epithelial cell line RWPE-1.
    [Histology and Histopathology]

    AbstractFull Article
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    REVIEWS

    A Systematic Review and Meta-Analysis of Placebo Effect in Clinical Trials on Chronic Prostatitis/Chronic Pelvic Pain Syndrome

    It is a common practice to control efficacy of pharmacological treatment with a placebo group. The authors evaluate the placebo effect on symptoms of chronic prostatitis/chronic pelvic pain syndrome to improve future clinical trials.
    [Prostate]

    Abstract

    Robot-Assisted Simple Prostatectomy vs Endoscopic Enucleation of the Prostate: A Systematic Review and Meta-Analysis of Comparative Trials

    Both endoscopic enucleation of the prostate (EEP) and robot-assisted simple prostatectomy (RASP) offer excellent improvement of symptoms due to prostatic hyperplasia. EEP has lower blood loss, shorter catheterization time, and length of hospital stay and should be the first choice if available.
    [Journal of Endourology]

    Abstract

    MR-Guided Radiotherapy for Prostate Cancer: State of the Art and Future Perspectives

    Scientists summarize the potential and current evidence for MRI-guided radiotherapy, with a predominant focus on prostate cancer.
    [British Journal of Radiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Japanese Prostate Cancer Imaging Trial Meets Study Objectives

    In collaboration with Kanazawa University, Telix Pharmaceuticals Limited announced that the Phase I clinical study of the company’s investigational prostate cancer imaging product in Japanese patients has reported the study results, which has met its objectives, demonstrating safety and tolerability when using TLX591-CDx.
    [Telix Pharmaceuticals Limited]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting

    April 7 – April 9
    Rome, Italy & Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Cancer Research

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Postdoctoral Fellow – Biomarker Discovery

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Postdoctoral Fellow – Androgen Synthesis

    Cleveland Clinic Lerner Research Institute – Cleveland, Ohio, United States

    Epidemiologist – Prostate Disease

    Henry M. Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States

    Postdoctoral Fellow – Targeted Therapy

    University of Maryland, Baltimore – Baltimore, Maryland, United States

    > See All Jobs

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