 | | Vol. 13.06 – 18 February, 2022 |
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| The authors revealed that melatonin concentration-dependently decreased the migratory and invasive abilities of two osteoblastic prostate cancer cell lines by inhibiting FAK, c-Src and NF-κB transcriptional activity via the melatonin MT1 receptor, which effectively inhibited integrin α2β1 expression.
[Journal of Pineal Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the mechanism altering mitochondrial function and oxidative phosphorylation in stress-induced senescent fibroblasts.
[Nature Communications] |
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| Investigators described that RelB participated in the immune evasion of prostate cancer via cis/trans transcriptional upregulation of programmed death receptor ligand (PD-L1).
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists assessed the dysregulation of the whole plasma miRNome in prostate cancer (PCa) patients, and its putative implication in PCa from a personalized perspective
[Molecular Therapy-Nucleic Acids] |
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| Researchers examined myokine levels of serum acquired from metastatic CRPC patients recruited to the INTERVAL-GAP4 trial before and after six months of exercise and its tumor-suppressive effect.
[Prostate Cancer and Prostatic Diseases] |
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| Germline mutations in DNA repair genes and KLK3 have been associated with adverse prostate cancer outcomes in separate studies but never jointly. The authors simultaneously assessed these two types of germline mutations.
[Prostate Cancer and Prostatic Diseases] |
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| Silencing LINC01963 inhibited TrkB protein level to enhance the chemosensitivity of PC3-DR to docetaxel by means of competitively binding to miR-216b-5p.
[Laboratory Investigation] |
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| The effects of UAP1-like-1 (UAP1L1) on prostate cancer were investigated by detecting the proliferation, migration, invasion and apoptosis of prostate cancer cells in vitro using MTT, wound healing, Transwell and flow cytometry assay, and the tumor growth in vivo.
[Journal of Translational Medicine] |
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| Researchers showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.
[Biophysical Journal] |
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| Investigators noted that circulating tumor cells isolated from prostate cancer patients displayed a specific mechanical phenotype, determined with atomic force microscopy: high softness and high adhesion.
[Biophysical Journal] |
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| Scientists investigated a possible role for protease-activated receptor-2 in regulating the behavior of bone cells exposed to metastatic prostate cancer cells.
[Prostate] |
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| The authors discuss the therapeutic potential of p53-reactivating compounds with a particular focus on the pharmacological rescue of p53 in metastatic prostate cancer.
[European Journal of Pharmacology] |
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| Positive results from the PROpel Phase III trial showed AstraZeneca and MSD’s Lynparza in combination with abiraterone demonstrated an improvement in radiographic progression-free survival versus current standard-of-care abiraterone as a first-line treatment for patients with metastatic CRPC.
[AstraZeneca] |
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| In January 2023, the US National Institutes of Health (NIH) will begin requiring most of the 300,000 researchers and 2,500 institutions it funds annually to include a data management plan in their grant applications — and to eventually make their data publicly available.
[Nature News] |
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| March 18 – March 21
Virtual |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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