 | | Vol. 13.07 – 25 February, 2022 |
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| Researchers reported that prostate leucine zipper (PrLZ) could be degraded by SPOP. PrLZ abundance was elevated in SPOP-mutant expressing prostate cancer cell lines and patient specimens.
[Cell Death & Differentiation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Genetic ablation of OTUD6A efficiently repressed prostatic tumorigenesis of both human prostate cancer (PrCa) cells and the Hi-Myc transgenic PrCa mice, via reversing the metabolic remodeling caused by c-Myc overexpression in PrCa.
[Cell Death & Differentiation] |
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| Via genome-scale CRISPR-Cas9 screening, scientists identified protein arginine methyltransferase 1 (PRMT1) as a critical mediator of androgen receptor expression and signaling.
[Cell Reports] |
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| Researchers integrated human studies, genetic mouse modeling, and cellular systems to characterize the regulation and function of glycine N-Methyltransferase in prostate cancer.
[Oncogenesis] |
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| Combination treatment of docetaxel with caffeic acid phenethyl ester effectively suppressed the proliferation and survival of docetaxel-resistant prostate cancer cells via inhibition of Bcl-2 and c-Myc as well as induction of metabolism interference.
[Journal of Biomedical Science] |
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| Investigators administrated Qi Ling (QL) to rats and collected the serum from QL-treated rats and established the co-culture system of tumor-associated macrophages/paclitaxel resistant prostate cancer cells.
[Aging] |
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| Liquid chromatography‑tandem mass spectrometry and gas chromatography‑mass spectrometry assays were performed, and the results revealed markedly reduced levels of glutamine and metabolic flux in the blood samples of patients with prostate cancer (PCa) and in PCa cells.
[International Journal of Oncology] |
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| The authors determined the influence of macrophage Trichomonas vaginalis macrophage migration inhibitory factor on prostate epithelial cells and its preliminary mechanism.
[andrology] |
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| Scientists analyzed the phytochemistry and screen the cytotoxic activity of new bioactive compounds against a panel of cancer cells, in addition to proapototic properties against prostate cancer cells.
[Daru-Journal of Pharmaceutical Sciences] |
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| The expression of HSP90 and IL-6 was upregulated and that of the androgen receptor was downregulated by knocking down lung cancer metastasis-related protein 1 or GRα in CRPC cells.
[Bioengineered] |
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| Scientists highlight key aspects of genetic testing in prostate cancer (PC), the role of clinicians, with a focus on primary care, the importance of obtaining a comprehensive family history, current germline testing guidelines, and the impact on precision PC care.
[Ca-A Cancer Journal For Clinicians] |
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| The authors discuss the role of TGF-β signaling in proliferation, metastasis and therapy response of prostate cancer cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-β such as non-coding RNAs are described.
[International Journal of Biological Macromolecules] |
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| Myovant Sciences announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending the approval of ORGOVYX® for the treatment of adult patients with advanced hormone-sensitive prostate cancer.
[Myovant Sciences] |
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| 2022-04-08-2022-04-13 |
New Orleans, Louisiana, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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