 | | Vol. 13.10 – 18 March, 2022 |
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| Investigators identified a recurrent mutation at position c.28 in the gene encoding the snRNA U2. This mutation was present in B cell derived tumors, as well as in prostate and pancreatic cancer, suggesting U2 c.28 constitutes a driver candidate associated with worse prognosis.
[NPJ Genomic Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The anti-prostate cancer effect of TF-3 was attributed to the expression of the 67 kDa laminin receptor (67LR), which is overexpressed in various cancers, playing a vital role in the growth and metastasis of tumor cells.
[Food & Function] |
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| Researchers performed molecular subtyping and prognostic assessment based on consensus genes in patients with prostate cancer. Five cohorts containing 1,046 prostate cancer patients with RNA expression profiles and recorded clinical follow-up information were included.
[Communications Biology] |
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| A constitutively-active mutant Akt1 restored Akt-mTOR activation but only partially ameliorated GNE-493-induced prostate cancer cell death. Moreover, GNE-493 was still cytotoxic in Akt1/2-silenced primary prostate cancer cells.
[Cell Death Discovery] |
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| The authors demonstrated a roadmap to develop and optimize bio-inks, ensuring printability, shape fidelity, and cell survivability.
[Journal of Manufacturing Processes] |
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| Human prostatic epithelial cells and RWPE-1 were induced by lipopolysaccharide to mimic chronic nonbacterial prostatitis model in vitro. Cell proliferation was determined using MTS assay.
[Inflammation Research] |
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| RT-qPCR was used to test the expression of SNHG11 in prostate cancer and benign prostate hyperplasia tissues, as well as in cell lines. Kaplan-Meier survival analysis and Cox regression assays were introduced to evaluate the prognostic meaning of SNHG11 in prostate cancer.
[Hormone and Metabolic Research] |
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| Scientists identified downregulated long noncoding RNA (lncRNA) growth arrest-specific 5 (GAS5) in prostate cancer that was associated with metastasis and paclitaxel resistance.
[Asian Journal of Andrology] |
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| Plate clone formation assay was performed to detect the effect of kaempferol on cell proliferation. Flow cytometry was used to detect the impact of kaempferol on cell apoptosis and cell cycle distribution.
[Molecular Biology Reports] |
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| Scientists smmarize the roles of Pumilio 1 and Pumilio 2 in cancer and discuss the factors that account for their distinct biological functions.
[Seminars in Cancer Biology] |
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| The authors’ analysis provides a snapshot of the current scenario regarding extracellular vesicles as potential clinical biomarkers in resistant prostate cancer.
[Prostate Cancer and Prostatic Diseases] |
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| Merck announced that it will stop the Phase II KEYLYNK-010 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with LYNPARZA, a PARP inhibitor, for the treatment of patients with metastatic CRPC who progressed after treatment with chemotherapy and other compounds.
[Imugene] |
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| May 13 – 18, 2022
San Francisco, California, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | BC Cancer Research Institute – BC Cancer Research Institute |
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