 | | Vol. 13.12 – 1 April, 2022 |
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| Scientists mapped potential pathways for citrate carbons in the human prostate cancer metastasis cell lines LNCaP and VCaP, for which they first established that they secrete citrate.
[Proceedings of the National Academy of Sciences of the United States of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Functional studies demonstrated that high GIPC2 expression due to CpG-island demethylation promoted increased metastatic capabilities of prostate cancer cells.
[Oncogene] |
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| Researchers investigated whether 5-aminolevulinic acid may increase the sensitization of prostate cancer cells to radiotherapy through the generation of reactive oxygen species via its metabolite, protoporphyrin IX.
[British Journal of Cancer] |
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| Vpr binding protein (VPRBP) knockdown in prostate cancer cells led to a significant decrease in cell proliferation, p53 stabilization, nucleolar fragmentation and increased p53 recruitment to the chromatin.
[Molecular Cancer Research] |
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| The authors investigated integrative genomics using a patient-derived xenograft model recapitulating acquired, androgen receptor-dependent CRPC.
[Communications Biology] |
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| Researchers found that knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo.
[Cell Death Discovery] |
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| LNCaP and VCaP cell lines in which androgen receptor (AR)-V7 expression could be induced to match the level of AR, were used to compare the activities of AR and AR-V7.
[Scientific Reports] |
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| The authors uncovered the role of GATA binding protein 5-mediated activation of transmembrane protein 100 in the proliferation, migration and epithelial-to-mesenchymal transition of prostate cancer cells.
[Bioengineered] |
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| Scientists evaluated, using flow cytometry, confocal microscopy and image analysis, the anti-proliferative effects of (+)-2,3,9-trimethoxypterocarpan on relevant human prostate cancer cells as well as its capacity to control mitosis within them.
[Chemistry & Biodiversity] |
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| Investigators assess the effects of prostatic arterial embolization compared to other procedures for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.
[Cochrane Database of Systematic Reviews] |
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| An integrative review was performed to critically synthesize findings on prostate cancer germline studies from published papers since 2016.
[Prostate Cancer and Prostatic Diseases] |
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| The authors focus on mismatch repair deficiency in prostate cancer, highlighting the clinical implications, the role of immunotherapy, and areas of future research.
[Prostate] |
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| Lantheus Holdings, Inc. announced a strategic collaboration with Novartis to include PYLARIFY® in prostate cancer clinical trials with Pluvicto™.
[Lantheus Holdings, Inc.] |
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| Accutar Biotechnology, Inc. announced the dosing of the first patient in a Phase I study of AC0176, an orally bioavailable, chimeric degrader molecule designed to target the androgen receptor with high potency and selectivity.
[Accutar Biotechnology, Inc.] |
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| May 30 – June 1, 2022
Brisbane, Queensland, Australia |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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