 | | Vol. 13.17 – 13 May, 2022 |
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Urinary Extracellular Vesicles Contain Mature Transcriptome Enriched in Circular and Long Noncoding RNAs with Functional Significance in Prostate Cancer | Dual analysis of extracellular vesicles (EVs)-lnc/circRNAs both in urines’ and in vitro’s EVs provided a fundamental resource for future uEV-lnc/circRNAs phenotypic characterization involved in prostate cancer.
[Journal of Extracellular Vesicles] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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MYC Drives Aggressive Prostate Cancer by Disrupting Transcriptional Pause Release at Androgen Receptor Targets | Researchers demonstrated that c-MYC (MYC) overexpression significantly diminished the androgen receptor (AR) transcriptional program in luminal prostate cells without altering AR expression.
[Nature Communications] |
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Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer | In prostate cancer cells, chronic hypoxia coupled to reoxygenation resulted in efficient metabolism of androgen precursors to produce androgens and activate androgen receptor.
[Cancer Research] |
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ADAM10-Cleaved Ephrin-A5 Contributes to Prostate Cancer Metastasis | Scientists concluded that a disintegrin and metalloprotease-10(ADAM10) -mediated ephrin-A5 shedding promoted prostate cancer metastasis via transforming the role of EphA3 from ligand-dependent tumor suppressor to ligand-independent promoter..
[Cell Death & Disease] |
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Identification of ISG15 and ZFP36 as Novel Hypoxia- and Immune-Related Gene Signatures Contributing to a New Perspective for the Treatment of Prostate Cancer by Bioinformatics and Experimental Verification | The authors developed a hypoxia- and immune-related gene risk signature and explore the molecular mechanisms to formulate a better prognostic tool for prostatic cancer patients.
[Journal of Translational Medicine] |
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Co-Delivery of Docetaxel and Resveratrol by Liposomes Synergistically Boosts Antitumor Efficiency against Prostate Cancer | Investigators designed PEGylated nano-liposomes for co-delivery Docetaxel and Resveratrol to evaluate antitumor efficiency of the combined drugs in prostate cancer.
[European Journal of Pharmaceutical Sciences] |
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Discrimination of Receptor-Mediated Endocytosis by Surface-Enhanced Raman Scattering | Receptor-mediated endocytosis was investigated with surface-enhanced raman scattering by inhibiting endocytosis with ATP depletion agents: sodium azide and 2-deoxy-d-glucose. Human lung bronchial epithelium cells, normal prostate epithelium cells, and cervical cancer epithelium cells were used as models.
[Langmuir] |
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Lycopene Enhances the Sensitivity of Castration-Resistant Prostate Cancer to Enzalutamide through the AKT/EZH2/ Androgen Receptor Signaling Pathway | Researchers provided data support for the combination of lycopene and enzalutamide in the treatment of CRPC.
[Biochemical and Biophysical Research Communications] |
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Orphan Receptors in Prostate Cancer | The authors review receptors that contribute to prostate cancer and are considered orphan or partially orphan. This means that the full spectrum of their endogenous ligands remains unknown.
[The Prostate] |
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How Tumor Cells Use Mitochondria to Keep Growing | CU Cancer Center Researcher Cecilia Caino, PhD, is studying the role of mitochondria in metastatic prostate cancer. Hormone therapy is often used to treat prostate cancer that has spread to other parts of the body, but many patients develop resistance to hormone therapy, causing their disease to become more aggressive and potentially more deadly.
[University of Colorado Cancer Center] |
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| November 3 – 6, 2022
Virtual |
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| | Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | University Hospital Frankfurt – Frankfurt, Germany |
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