 | | Vol. 13.21 – 17 June, 2022 |
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| ACK1 kinase–mediated androgen press release Y267 phosphorylation was a prerequisite for AR K609 acetylation, which spawned positive feedback loops at both the transcriptional and posttranslational level that regenerated and sustained high androgen receptor and ACK1 expression.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that the two key components of the mitochondrial unfolded protein response, heat shock protein 60 and caseinolytic protease were required for the development of advanced prostate cancer.
[Journal of Clinical Investigation] |
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| For the enhanced killing of PCa cells that were either androgen-dependent or not, the combination of superparamagnetic iron oxide nanoparticles based etoposide delivery and mild hyperthermia triggered by laser irradiation is proposed for the first time in the literature.
[Biomaterials Science] |
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| Co-expression networks were constructed and survival analysis was applied to hub genes. Drug candidates to alleviate immunosuppression were filtered in prostate cancer using GSEA based on hub genes.
[Aging] |
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| Researchers found α- terthienyl could inhibit the cell viability of four prostate cancer cell lines, especially on LNCaP and 22Rv1 cells which endogenously express androgen receptor.
[Biomedicine & Pharmacotherapy] |
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| Scientists characterized ADPC and neuroendocrine prostate cancer in prostate tumors from seven patients using scRNA-seq.
[iScience] |
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| Investigators designed a highly tunable microfluidic device that induced hypoxia through natural cell metabolism and oxygen diffusion barriers.
[ACS Biomaterials Science & Engineering] |
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| Researchers demonstrated that apigenin arrests prostate cancer cells at G2 phase by flow cytometric analysis of prostate cancer cells co-stained for phospho-Histone H3 and DNA.
[Discover Oncology] |
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| Studies have shown that the P2X7 receptor is abnormally expressed in prostate cancer, and is related to the level of prostate-specific antigen, P2X7 receptor may be an early biomarker of prostate cancer.
[Human Cell] |
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| The O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham has been awarded a five-year Cancer Center Core Support Grant of $27,477,570 from the National Cancer Institute.
[The University of Alabama at Birmingham] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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