Prostate Cell News Volume 13.22 | Jun 24 2022

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    2022-05-24 | PCN 13.22


    Prostate Cell News by STEMCELL Technologies
    Vol. 13.22 – 24 June, 2022
    TOP STORY

    Ellagic Acid Improves Benign Prostate Hyperplasia by Regulating Androgen Signaling and STAT3

    To investigate the effect of ellagic acid (EA) on benign prostate hyperplasia, researchers used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate-induced benign prostate hyperplasia rats and RWPE-1 human prostate epithelial cells.
    [Cell Death & Disease]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Hippo Pathway Monomerizes STAT3 to Regulate Prostate Cancer Growth

    Scientists showed that high cell density-mediated activation of Hippo pathway blunted STAT3 activity in prostate cancer cells.
    [Cancer Science]

    Abstract

    Leptin Modulated MicroRNA-628-5p Targets Jagged-1 and Inhibits Prostate Cancer Hallmarks

    Investigators examined the detailed cellular phenotypes and pathways regulated by miR-628 in prostate cancer cells.
    [Scientific Reports]

    Full Article

    Dual STAT-3 and IL-6R Inhibition with Stattic and Tocilizumab Decreases Migration, Invasion and Proliferation of Prostate Cancer Cells by Targeting the IL-6/IL-6R/STAT-3 Axis

    Researchers investigated the effect of Stattic and Tocilizumab on proliferative, clonogenic, migratory, and invasive ability of human metastatic prostate cancer, as assessed by colony formation, wound healing, and migration assay.
    [Oncology Reports]

    Abstract

    CKAP2L, a Crucial Target of miR-326, Promotes Prostate Cancer Progression

    Cytoskeleton associated protein 2 like (CKAP2L) expression was examined in the normal and tumor tissues of prostate cancer patients with RT-QPCR and Western blot.
    [BMC Cancer]

    Full Article

    Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single-Cell Transcriptomes

    Investigators identified two prostate cancer (PC) subtypes: PC immunity high and PC immunity low, consistently in ten different bulk tumor transcriptomic datasets and in a single-cell RNA-Seq dataset.
    [Medical Oncology]

    Abstract

    miR-27 and miR-124 Target AR Coregulators in Prostate Cancer: Bioinformatics and In Vitro Analysis

    The authors identified miRNAs targeting androgen receptor (AR) coregulators. They examined target genes by combining miRNA-mRNA computational and experimental data from various databases.
    [Andrologia]

    Abstract
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    REVIEWS

    Prostate Organogenesis

    The fields of developmental and cancer biology have long been interested in prostate organogenesis because of its relevance for understanding prostate disease.
    [Development]

    Abstract

    Androgen and Androgen Receptor Control of Mitochondrial Function

    Scientists highlight the effects that androgens have on mitochondrial structure and function with emphasis on biogenesis, fusion/fission, mitophagy, bioenergetics, and reactive oxygen species production.
    [American Journal of Physiology-Cell Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    $3.5M Study to Better Predict Prostate Cancer Risk

    To increase public understanding of the causes of prostate cancer, the University of Hawaiʻi Cancer Center will lead a $3.5 million public impact research study to further our understanding of prostate cancer to improve prediction of future disease.
    [University of Hawai’i News]

    Press Release
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