Prostate Cell News Volume 13.25 | Oct 28 2022

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    Noshin Noorjahan
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    2022-10-28 | PCN 13.25


    Prostate Cell News by STEMCELL Technologies
    Vol. 13.25 – 28 October, 2022
    TOP STORY

    A Cryptic Transactivation Domain of EZH2 Binds AR and AR’s Splice Variant, Promoting Oncogene Activation and Tumorous Transformation

    Scientists reported that a cryptic transactivation domain of Enhancer of Zeste Homolog 2 (EZH2) binds both androgen receptor (AR) and AR spliced variant 7 mediating assembly and/or recruitment of transactivation-related machinery at genomic sites that lack polycomb repressive complex 2 binding.
    [Nucleic Acids Research]

    Full Article
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    PSMA1-Mediated Ultrasmall Gold Nanoparticles Facilitate Tumor Targeting and MR/CT/NIRF Multimodal Detection of Early-Stage Prostate Cancer

    Investigators devised a multimodal contrast agent that featured highly-effective prostate-specific membrane antigen (PSMA) targeting and desired molecular pharmacokinetics for prostate cancer diagnosis.
    [Nanomedicine: Nanotechnology, Biology and Medicine]

    AbstractGraphical Abstract

    Knockdown of USP8 Inhibits Prostate Cancer Cell Growth, Proliferation, and Metastasis and Promotes Docetaxel’s Activity by Suppressing the NF-kB Signaling Pathway

    Prostate cancer cell lines DU145 and PC3 were transfected with ubiquitin-specific protease 8 siRNA or overexpressing vector together with or without docetaxel.
    [Frontiers in Oncology]

    Full Article

    Arglabin, an EGFR Receptor Tyrosine Kinase Inhibitor, Suppresses Proliferation and Induces Apoptosis in Prostate Cancer Cells

    Arglabin, a sesquiterpene lactone isolated from Artemisia glabella, was cytotoxic to different human cancer cell lines including those derived from advanced triple-negative breast, lung, and androgen-dependent and androgen-independent prostate carcinomas.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Juglone Promotes Antitumor Activity against Prostate Cancer via Suppressing Glycolysis and Oxidative Phosphorylation

    Researchers investigated the effect of juglone on energy metabolism in prostate cancer cells and found that juglone inhibited cell proliferation and induced apoptosis.
    [Phytotherapy Research]

    Abstract

    Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in In Vitro Models of Prostate Cancer Drug Resistance

    Scientists reported the synthesis and biological characterization of a novel class of compounds designed through covalently linking enzalutamide and epichlorohydrin scaffolds-001 through various triazole based linkers.
    [ChemMedChem]

    AbstractFull Article

    UHPLC-MS/MS-GNPS Based Phytochemical Investigation of Dryopteris ramosa (Hope) C. Chr. and Evaluation of Cytotoxicity against Liver and Prostate Cancer Cell Lines

    The authors investigated the detailed phytochemical profile of Dryopteris ramosa and its cytotoxic potential using various cancer cell lines.
    [Heliyon]

    Full Article
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    REVIEWS

    The Diagnostic Role and Mechanistic Functions of Exosomal lncRNAs in Prostate Cancer

    Researchers focus on the summary of diagnostic roles and mechanistic functions of exosomal long non-coding RNAs in prostate cancer.
    [Clinical and Translational Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    The Prostate Cancer Foundation Announces 2022 Young Investigator Awards Totaling $7.2 Million for Prostate Cancer Research

    The Prostate Cancer Foundation announced the Class of 2022 Young Investigator Award recipients totaling $7.2 million in funding for innovative prostate cancer research.
    [Prostate Cancer Foundation]

    Press Release

    Prostate Cancer Centre of Excellence to Open at Queen’s Thanks to £1.6M Donation

    A new Prostate Cancer Centre of Excellence is set to open at Queen’s University Belfast, thanks to a generous £1.6million gift to establish a clinical research facility at the Patrick G. Johnston Centre for Cancer Research.
    [Queen’s University Belfast]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

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    University of Cambridge – Cambridge, England, United Kingdom

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