 | | Vol. 13.28 – 25 November, 2022 |
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| Scientists sequenced plasma circulating tumor DNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active and neuroendocrine prostate cancers.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that inhibitors of the mitotic regulator polo-like kinase-1 (Plk1), including the Plk1 inhibitor onvansertib, synergized with abiraterone in vitro and in vivo to kill a subset of cancer cells from a wide variety of tumor types in an androgen-independent manner.
[Cancer Research] |
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| A bombesin installed nanoplatform combining the chemotherapeutic mitoxantrone (MTO) and the chemotherapeutic sensitizer of nitric oxide (NO) was developed based on MTO-loaded macromolecular NO-donor-containing polymeric micelles for targeted NO-sensitized chemotherapy against prostate cancer.
[Advanced Healthcare Materials] |
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| Researchers investigated the effect of hsa_circ_0070512 on the function and mechanism of prostate cancer (PCa). hsa_circ_0070512 was increased in PCa tissues and cells, and was mostly found in the cytoplasm of PCa cells.
[Cancer Science] |
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| A total of 103 samples were collected, including 62 DNA samples from the tumor tissues of 59 hormone-sensitive prostate cancer patients and 41 cell-free DNA samples from prostate cancer patients at different cancer stages.
[Prostate Cancer and Prostatic Diseases] |
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| By mining public datasets, investigators discovered that the expression of acetyl-CoA carboxylase alpha, which encoded acetyl-CoA carboxylase 1, was highly expressed in human prostate cancer.
[Journal of Biological Chemistry] |
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| The authors examined the effect of androgen signaling on MYB expression. Paralleling a dichotomous effect on growth, low-dose androgen induced MYB expression at both transcript and protein levels whereas it was suppressed in high-dose androgen-treated cells.
[Journal of Biological Chemistry] |
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| Scientists explored the new role of resveratrol in vasculogenic mimicry incidence in human prostate cancer PC-3 cells.
[Scientific Reports] |
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| Researchers showed that yuanhuacine dose-dependently inhibited the proliferation and induced apoptosis of prostate cancer (PCa) cells. Yuanhuacine also restrained the invasion and migration of PCa cells.
[Journal of Biochemical and Molecular Toxicology] |
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| Prostate cancer is often found in men undergoing holmium laser enucleation of the prostate and can be challenging to manage. Further work is still needed on variables associated with the detection of incidental prostate cancer and strategies to reduce incidental prostate cancer.
[Nature Reviews Urology] |
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| Clarity Pharmaceuticals announced the approval of its Investigational New Drug (IND) application by the US FDA to evaluate its SAR-Bombesin product for the identification and treatment of metastatic castrate-resistant prostate cancer.
[Clarity Pharmaceuticals] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Novartis – St. Louis, Missouri, United States |
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| | City of Hope – Los Angeles, California, United States |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | Columbia University Irving Medical Center – New York, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Intestinal Cell News
Mammary Cell News
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Neural Cell News
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Pancreatic Cell News
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