 | | Vol. 13.30 – 9 December, 2022 |
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| Scientists reported that PALI1 was upregulated in advanced prostate cancer and competed with JARID2 for binding to the polycomb repressive complex 2 (PRC2) core subunit SUZ12.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported high levels of androgen receptor chromatin binding heterogeneity in human primary prostate tumors, that overlapped with heterogeneity observed in healthy prostate epithelium.
[Nature Communications] |
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| Five cohorts from The Cancer Genome Atlas and Gene Expression Omnibus databases were used to perform gene set variation analysis between nonrecurrent and recurrent prostate cancer patients.
[Cancer Cell International] |
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| The authors investigated the metabolic alterations induced by the Zika virus in PNT1a and PC-3 cells using an untargeted metabolomics approach and high-resolution mass spectrometry.
[Journal of Proteome Research] |
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| Four different cell lines, including ACHN, 5637, LNCaP, and PC3 were exposed to diverse concentrations of mesenchymal stem cells-derived exosomes to find IC50 values.
[Scientific Reports] |
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| Scientists fabricated the Bismuth oxide (Bi2O3) nanoparticles, functionalized with glutamine and conjugated with Thiosemicarbazide, and then investigated their anticancer mechanism.
[Scientific Reports] |
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| CK-8 assay, colony formation experiment, Transwell migration, and invasion experiments were performed to prove that the upregulation of LINC00852 could promote the proliferation, migration, and invasion of prostate cancer cells in vitro.
[BMC Cancer] |
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| Investigators examined the functional and biological roles of phosphorylation. Androgen receptor phosphorylation at Ser815 stabilized homodimer formation in the cytoplasm, interrupting DHT-response nuclear translocation.
[Biochemical and Biophysical Research Communications] |
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| Two different cell models were employed and compared. Small extracellular vesicles from androgen-dependent prostate cancer (PCa) cells and androgen-independent PCa cells were isolated and characterized.
[Heliyon] |
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| The authors discuss the main mesenchymal cell populations of the prostate stroma, highlighting their dynamic role in the transition of the healthy prostate epithelium to cancer.
[British Journal of Cancer] |
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| The Prostate Cancer Foundation announced four inaugural Class of 2022 TACTICAL award recipients. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st century therapies for the most life-threatening form of prostate cancer.
[Prostate Cancer Foundation] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | Novartis – East Hanover, New Jersey, United States |
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| | Pfizer – Collegeville, Pennsylvania, United States |
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