 | | Vol. 14.00 – 6 January, 2023 |
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| Scientists identified a novel tumor-mediated mechanism that repressed the expression of thrombospondin-1 (Tsp-1) in the tumor microenvironment via secretion of the serine protease PRSS2.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By heterologous gain of human ETS related gene (ERG) in Drosophila, researchers revealed Chip, which coded for a transcriptional coactivator, LIM-domain-binding protein, as its novel target.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators showed that AF-1 and the AR-V7 splice variant formed molecular condensates that exhibited disorder characteristics such as rapid intracellular mobility, coactivator interaction, and euchromatin induction.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors reported that solute carrier family 12 member 5 functioned as an oncogene to promote tumor progression and castration resistance of prostate cancer through the N6-methyladenosine (m6A) reader YTHDC1 and the transcription factor HOXB13.
[Cell Death & Disease] |
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| Researchers reported that the level of AKR1C3 was reciprocally regulated by the full-length androgen receptor through binding to the distal enhancer region of the AKR1C3 gene.
[Oncogene] |
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| The effect of different applied voltages of irreversible electroporation on prostate cancer was evaluated in BALB/c nude mice.
[Scientific Reports] |
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| RT-qPCR analysis was used to test gene expression. CCK-8, colony formation, EdU staining, and transwell assays were conducted to assess the function of DNMBP antisense RNA 1 (DNMBP-AS1) on prostate cancer cell behaviors.
[Systems Biology in Reproductive Medicine] |
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| Scientists investigated the potential regulatory mechanism of AKT1 on ubiquitin-like containing PHD Ring Finger 1 (UHRF1), and further validated the in vitro and in vivo anticancer efficacy of AKT phosphorylation inhibitor MK2206 in combination with abiraterone.
[Oncogenesis] |
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| The antiproliferative effect of both free curcumin and CurcuEmulsome were investigated comparatively on LNCaP and PNT1A cells.
[Molecular Biology Reports] |
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| Several prospective studies of prostate cancer incidence and screening among BRCA1/2 mutation carriers have indicated at least a twofold to fourfold increase in prostate cancer risk among carriers of BRCA2 mutations compared with the general population.
[Nature Reviews Urology] |
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| The authors review the role of major types of ion channels involved in the development and progression of prostate cancer.
[Molecular Diagnosis & Therapy] |
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| Investigators provide an overview on the roles of prostate-derived proteolytic enzymes in prostate cancer with a special focus on their regulation by androgens.
[IUBMB Life] |
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| Acer Therapeutics, Inc. announced the initiation of two Phase II, single-arm investigator-sponsored trials evaluating ACER-801 in men with adenocarcinoma of the prostate.
[Acer Therapeutics, Inc.] |
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| March 15 – 18, 2023
Denver, Colorado, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | UTHSC-Houston – Houston, Texas, United States |
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| | Washington State University – Spokane, Washington, United States |
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