 | | Vol. 14.02 – 20 January, 2023 |
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| Researchers showed that phosphorylation of tyrosine 344 occured and was required for 3β-hydroxysteroid dehydrogenase-1 (3βHSD1) cellular activity and generation of Δ4, 3-keto-substrates of 5α-reductase and aromatase, including in patient tissues.
[Journal Of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed genome-wide CRISPR-Cas9 knockout screens in BRCA1/2-proficient prostate cancer cells and identified previously unknown genes whose loss had a profound impact on poly (ADP-ribose) polymerase inhibitor response.
[Nature Communications] |
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| Investigators found and identified a bifunctional small molecule Z15, which was both an effective androen receptor (AR) antagonist and a selective AR degrader.
[Elife] |
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| To evaluate the association between fatty acid synthase (FASN) expression, methylation, prognosis, and mutational profile in pancreatic ductal adenocarcinoma and prostate cancer, researchers interrogated public databases and surveyed online platforms using TCGA data.
[Journal of Translational Medicine] |
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| Ser/Arg repetitive matrix 4 (SRRM4) expression and RE1-silencing transcription factor (REST) splicing were analyzed by RT-qPCR and conventional RT-PCR after treating SRRM4 antisense oligonucleotide, and cell viability was analyzed in vitro.
[Cancer Cell International] |
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| The authors investigated the effect of fatty acid-binding protein 5 (FABP5) inhibitors on apoptosis and studied the relevant mechanisms. Wild type recombinant FABP5 significantly reduced apoptotic cells in 22Rv1 and PC3 by 18% and 42%, respectively.
[Cell Biology International] |
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| To search for compounds which overcame the resistance to apalutamide, scientists established apalutamide-resistant prostate cancer 22Rv1 cells (22Rv1/APA). The 22Rv1/APA cells showed higher androgen receptor expression and androgen sensitivity than parental 22Rv1 cells.
[Archives of Biochemistry and Biophysics] |
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| The anticancer activities of the N-benzyl-2-oxo-1,2-dihydrofuro pyrimidine-3(4H)-carboxamide were determined on human colon cancer and prostate cancer cell lines.
[Heliyon] |
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| Researchers established stable cell lines, DU145 and PC-3, transfected with either empty vector or the full-length YTH domain-containing protein 2 (YTHDC2) gene and conducted cell function assays in vitro.
[Journal of Biochemical and Molecular Toxicology] |
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| Although few prostate cancer patient-derived xenografts (PDXs) are available in large repositories, more PDXs are needed to reflect patient diversity, and to study new treatments and emerging mechanisms of resistance.
[Nature Reviews Urology] |
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| The China government has abandoned its ‘zero-COVID’ policy and researchers from inside and outside the country are organizing to meet.
[Nature] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | City of Hope – Duarte, California, United States |
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| | Novartis – San Francisco, California, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Stanford Medicine – Stanford, California, United States |
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