 | | Vol. 14.03 – 27 January, 2023 |
| |
|
|
| The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[British Journal of Cancer] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.
[British Journal of Cancer] |
|
|
|
| Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.
[International Journal of Radiation Oncology*Biology*Physics] |
|
|
|
| Scientists investigated the regulatory effects of estrogens on endoplasmic reticulum (ER)-associated degradation (ERAD) and unfolded protein response (UPR) and their impacts on prostate carcinogenesis.
[Journal of Cell Communication and Signaling] |
|
|
|
| To explore the molecular mechanism of intra-vesical prostatic protrusion (IPP) formation, investigators performed RNA sequencing on prostate tissue stromal cells obtained from IPP-derived primary cultures.
[Gerontology] |
|
|
|
| Researchers identified prostate cancer (PCa) subtypes and constructed a gene signature that could predict the recurrence-free survival of PCa patients based on chromatin regulators genes.
[Frontiers in Genetics] |
|
|
|
| The authors demonstrated that three out of four tested prostate cancer cell lines pretreated with mycotoxin deoxynivalenol increased tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-induced apoptosis detected with flow cytometry.
[Toxicology and Applied Pharmacology] |
|
|
|
| Viscosalactone B was first identified as a novel lysine-specific demethylase 1 (LSD1) inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells.
[Investigational New Drugs] |
|
|
|
| Scientists investigated the role and molecular mechanism of glioblastoma downregulated RNA (GLIDR) in prostate cancer (PCa) cells. The results showed that GLIDR expression levels were higher in PCa samples and cells than in the control.
[PATHOLOGY RESEARCH AND PRACTICE] |
|  |
|
|
|
| The authors describe the current evidence regarding the accuracy and efficacy of miRNAs as biomarkers for prostate cancer.
[Future Oncology] |
|
|
|
| Investigators analyze the current imaging and treatment options for neuroendocrine Prostate Cancer, and to highlight future potential treatment strategies.
[Expert Review of Anticancer Therapy] |
|
|
|
| Scientists review the roles of noncanonical wingless-type MMTV integration site family (WNT) signaling pathways, chromatin remodelers, and epigenetic enzymes in the development and progression of prostate cancer.
[Asian Journal of Andrology] |
|
|
|
|
| Alpha-9 Theranostics, a UBC spin-off company founded by three university researchers, had raised $75 million to develop next-generation radiopharmaceuticals that promise to meaningfully improve treatment for people with cancer.
[UBC Faculty of Medicine] |
|
|
|
| Merck & Co Inc. said it was discontinuing a late-stage trial of its blockbuster immunotherapy Keytruda in some prostate cancer patients after interim data showed it was unlikely to meet the study’s main goals.
[Reuters] |
|
|
|
|
| April 17 – 19, 2023
Freiburg im Breisgau, Germany |
|
|
|
|
|
| | Novartis – East Hanover, New Jersey, United States |
|
|
|
| | City of Hope – Duarte, California, United States |
|
|
|
| | Pompeu Fabra University – Barcelona, Spain |
|
|
|
| | Stanford Medicine – Stanford, California, United States |
|
|
|
| | University Medical Center Freiburg – Freiburg, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
