 | | Vol. 14.05 – 10 February, 2023 |
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| The authors described the identification of glypican-3 as an oncofetal cell surface protein specific to neuroendocrine cells in prostate cancer.
[Journal Of Pathology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By co-culturing prostate cancer (PCa) cells with osteoblasts to mimic PCa bone metastases, investigators found that RBM3 upregulated the N6-methyladenosine methylation on the mRNA of catenin beta 1 (CTNNB1) in a manner dependent on methyltransferase 3.
[Cell Death & Disease] |
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| Scientists found that upregulation of hyaluronan-mediated motility receptor (HMMR) was observed in prostate cancer (PCa) samples and was associated with poor prognosis. HMMR significantly promoted PCa proliferation and metastasis through gain- and loss-of function approaches in vitro and in vivo.
[Cell Death Discovery] |
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| Researchers demonstrated that cadmium exposure reduced the levels of mitochondrially-localized signal transducer and activator of transcription 3 (STAT3) using human prostate stromal cells and mouse embryonic fibroblasts.
[Communications Biology] |
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| To test whether DNA methylation could result in the reduced expression of calcium/calmodulin-dependent protein kinase II inhibitor I (CAMK2N1) in prostate cancer, the DNA methylation level of CAMK2N1 in prostate cells was determined by bisulfite sequencing, pyrosequencing, and in silico analysis.
[Journal Of Oncology] |
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| Investigators evaluated the molecular mechanisms through which cholinergic receptor muscarinic 3 (CHRM3) overexpression facilitated castration-resistant growth. Small RNA-sequencing combined with in silico analyses revealed that CHRM3 was a putative target of miR-15b-5p.
[Febs Letters] |
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| Scientists extended the concept of 5-fluorouracil/heme oxygenase 1 (5-FU/HO-1) inhibitor hybrid as an effective strategy for enhancing 5-FU-based anticancer therapies.
[Chemmedchem] |
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| To examine whether HIF-1α in the hypoxic microenvironment mediates the transformation of prostate cancer to a stem cell phenotype, prostate cancer stem cells from PC-3 cell lines were examined for the expression of CD44, CD133, ALDH1, HIF-1α, Notch1, and HES1.
[Clinical and Translational Oncology] |
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| Researchers investigated the functionalization of gold nanoparticles with D2B to generate favorable physicochemical and biological properties that mediate specific binding to prostate cancer.
[Acs Applied Bio Materials] |
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| The authors review and discuss the up-to-date knowledge on atypical chemokine receptor 3 (CXCR7) regulation and function and how this new understanding guides the development of CXCR7 inhibitors, focusing on prostate cancer.
[Oncogene] |
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| A total of 54 projects led by UBC Faculty of Medicine researchers were awarded more than $26 million in combined funding through the Canadian Institutes of Health Research Project Grant: Fall 2022 competition.
[UBC Faculty of Medicine] |
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| The Canadian Institutes of Health Research will be providing more than $1.3 million in grants to researchers at Lakehead University.
[Lakehead University] |
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| March 31, 2023
Amsterdam, The Netherlands |
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| | University of Rochester Medical Center – Rochester, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Imperial College Healthcare – London, England, United Kingdom |
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| | Vancouver Prostate Centre – Vancouver, British Columbia, Canada |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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