 | | Vol. 14.06 – 17 February, 2023 |
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| Investigators showed that a novel heat shock protein 70 (HSP70) allosteric inhibitor, JG98, significantly suppressed drug-resistant C4-2B MDVR and CWR22Rv1 cell growth, and enhanced enzalutamide treatment.
[Pharmacological Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that acute or chronic cadmium exposure facilitated NADPH oxidase 1 (NOX1) assembly by activating its cytosolic regulators p47phox and p67phox in RWPE-1 cells.
[Free Radical Biology And Medicine] |
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| Investigators reported that cardiac glycoside neriifolin suppressed the malignancy of cancer cells via increasing DNA damage and apoptosis through activation of endoplasmic reticulum stress in prostate cancers.
[Biochemical Pharmacology] |
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| Scientists introduced the synthesis of novel 17α- and/or 21-ester or carbamate derivatives of hydrocortisone and evaluation of their biological activity towards androgen and glucocorticoid receptors in different prostate cancer cell lines.
[Journal Of Steroid Biochemistry And Molecular Biology] |
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| The authors investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptors, and the contribution of IL-8 to prostate cancer aggressiveness.
[Biomolecules & Therapeutics] |
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| Scientists discovered that MEIS homeobox 2 was lowly expressed in prostate cancer tissues by bioinformatics analysis, which had a close connection with the T stage and N stage of the tumor.
[Chemical Research In Toxicology] |
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| The therapeutic effects of sonodynamic, photodynamic, and sonophotodynamic of 5-(trifluoromethyl)-2-thiopyridine substituted SiPc and its quaternized derivative were examined in vitro on prostate cancer using PC3 cells.
[Photodiagnosis And Photodynamic Therapy] |
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| Researchers used a novel in vitro approach, involving the exposure of prostate cancer cells to sera from obese or normal-weight males, and to calcium sensing receptor inhibitor NPS-2143.
[Nutrition And Cancer-An International Journal] |
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| Scientists investigated the biological role of and mechanisms of circ_0085494 in prostate cancer.
[Biochemical Genetics] |
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| To ensure maximal transfer of knowledge from scientific research to the clinic, understanding the limitations and advantages of preclinical models, as well as how these models recapitulate cancer cell androgen dependency and can be used to study castration resistance mechanisms, is essential.
[Nature Reviews Urology] |
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| The authors elaborate on the role of hypoxia in prostatic cancer pathogenesis and different hypoxia-induced mechanisms.
[Molecular Biology Reports] |
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| RadioMedix, Inc. announced the acquisition of its 225Ac-PSMA-I&T asset by Fusion Pharmaceuticals. RadioMedix will provide manufacturing support for the first pivotal clinical trial to evaluate the safety and efficacy of 225Ac-PSMA-I&T for metastatic castration-resistant prostate cancer.
[RadioMedix, Inc. (Globe Newswire)] |
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| February 22 – 23, 2023
Boston, Massachusetts, United States |
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| | Vancouver Prostate Centre – Vancouver, British Columbia, Canada |
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| | Imperial College Healthcare – London, England, United Kingdom |
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| | Vancouver Prostate Centre – Vancouver, British Columbia, Canada |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Rochester Medical Centre – Rochester, New York, United States |
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