Prostate Cell News Volume 14.08 | Mar 3 2023

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    2023-03-03 | PCN 14.08


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.08 – 3 March, 2023
    TOP STORY

    Rewiring of the N-glycome with Prostate Cancer Progression and Therapy Resistance

    Scientists profiled the N-linked glycans in tumor tissue derived from 131 prostate cancer patients to identify glycosylation changes associated with loss of tumor cell differentiation, therapy resistance, and disease recurrence, as well as neuroendocrine differentiation which is a major mechanism for therapy failure.
    [Npj Precision Oncology]

    Full Article
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    NRP1 Promotes Prostate Cancer Progression via Modulating EGFR-Dependent AKT Pathway Activation

    Researchers observed that NRP1 was highly expressed in prostate cancer and associated with poor prognosis in prostate cancer patients.
    [Cell Death & Disease]

    Full Article

    TPM2 Attenuates Progression of Prostate Cancer by Blocking PDLIM7-Mediated Nuclear Translocation of YAP1

    Scientists investigated the role of tropomyosins 2 (TPM2), PDLIM7, and YAP1 in prostate progression and castration resistance.
    [Cell And Bioscience]

    Full Article

    Reversible Epigenetic Alterations Mediate PSMA Expression Heterogeneity in Advanced Metastatic Prostate Cancer

    Investigators demonstrated that prostate-specific membrane antigen (PSMA) expression was heterogeneous across different metastatic sites and molecular subtypes of metastatic castration-resistant prostate cancer.
    [JCI Insight]

    AbstractGraphical Abstract

    Trigred Motif 36 Regulates Neuroendocrine Differentiation of Prostate Cancer via HK2 Ubiquitination and GPx4 Deficiency

    Researchers found that Trigred motif 36 was lowly expressed in neuroendocrine prostate cancer, and its overexpression suppressed the neuroendocrine differentiation of prostate cancer.
    [Cancer Science]

    Abstract

    In Silico, In Vitro and In Vivo Studies: Dibutyl Phthalate Promotes Prostate Cancer Cell Proliferation by Activating Forkhead Box M1 and Remission after Natura-α Pretreatment

    Scientists investigated the specific mechanism through which dibutyl phthalate promoted prostate cancer cell proliferation. They found protective measures – Natura-α which could be helpful to mitigate this effect.
    [Toxicology]

    Abstract

    Cannabidiol and Cannabis sativa as a Potential Treatment In Vitro Prostate Cancer Cells Silenced with RBBp6 and PC3 Xenograft

    Investigators demonstrated that cannabidiol was a viable therapy to treat prostate cancer cells, in combination with the silencing of retinoblastoma binding protein 6 (RBBP6). This suggested that cannabidiol rather Cannabis sativa extract may play an important role in reducing cancer progression.
    [Molecular Biology Reports]

    Full Article

    Euchromatic Histone Lysine Methyltransferase 2 Facilitates Radioresistance in Prostate Cancer by Repressing Endoplasmic Reticulum Protein 29 Transcription

    Researchers studied the role of euchromatic histone lysine methyltransferase 2 (EHMT2) and endoplasmic reticulum protein 29 (ERP29) in the progression of radioresistance in prostate cancer.
    [Kaohsiung Journal Of Medical Sciences]

    Full Article

    KIF14 Mediates Cabazitaxel-Docetaxel Cross-Resistance in Advanced Prostate Cancer by Promoting AKT Phosphorylation

    Scientists used docetaxel-resistant cell lines DU145/DTX50 and PC-3/DTX30 to measure the responses to cabazitaxel.
    [Archives Of Biochemistry And Biophysics]

    Full ArticleGraphical Abstract
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    REVIEWS

    Molecular Predictors of Metastasis in Patients with Prostate Cancer

    The authors introduce a large number of predictive molecules related to prostate cancer metastasis. These molecules involve the mutation and regulation of tumor cell genes, changes in the tumor microenvironment, and the liquid biopsy.
    [Expert Review Of Molecular Diagnostics]

    Abstract

    Potential Role for Protein Kinase D Inhibitors in Prostate Cancer

    Investigators focus on protein kinase D (PrKD) signaling in prostate cancer and the potential role of PrKD inhibitors therein and explore the possible clinical outcomes based on known function and expression of PrKD isoforms at different stages of prostate cancer.
    [Journal Of Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Darolutamide Receives EU Approval for Additional Indication in Prostate Cancer

    The European Commission granted marketing authorization in the European Union for darolutamide, an oral androgen receptor inhibitor, plus androgen deprivation therapy in combination with docetaxel, for the treatment of patients with metastatic hormone-sensitive prostate cancer.
    [Orion, Corp.]

    Press Release
    FEATURED EVENT

    Cell Symposium: Viruses in Health and Disease

    March 19 – 21, 2023
    Sitges, Spain

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    JOB OPPORTUNITIES

    Research Assistant Professor – Urology

    University of Miami – Miami, Florida, United States

    Study Coordinator – Prostate Cancer Studies

    University of Tasmania – Tasmania, Australia

    Postdoctoral Research Fellow – Cancer Biology

    The Henry Ford Health System – Detroit, Michigan, United States

    Program Coordinator – Prostate Cancer Supportive Care

    Vancouver Prostate Centre – Vancouver, British Columbia, Canada

    Research Technician – Genitourinary Cancers

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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