 | | Vol. 14.13 – 14 April, 2023 |
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| The authors reported broad expression of STEAP1 relative to prostate-specific membrane antigen in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric antigen receptor T cell therapy.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that conditional deletion of PTEN in the murine prostate epithelium caused an expansion of transformed LY6D+ progenitor cells without impairing stem cell properties.
[Cell Reports] |
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| Scientists identified a novel signaling pathway linking hypoxia and Proviral Integration site for Moloney murine leukemia virus (PIM) 1 kinase to the actin cytoskeleton and cell motility.
[Journal of Cell Biology] |
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| The authors found that very small size particles (VSSP) decreased tumor-associated macrophages and inhibited prostatic tumor growth when administered to castrated Pten-deficient prostate tumor-bearing mice.
[Cell Communication and Signaling] |
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| SMYD2 knockdown cells were established to identify the effects of SMYD2 on prostate cancer cell growth in vitro and in vivo.
[Molecular Carcinogenesis] |
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| Scientists analyzed the expression of wild-type vs. truncated high mobility group A2 (HMGA2) and showed that prostate cancer patient tissue and some cell lines expressed increasing amounts of both wild-type and truncated HMGA2 with increasing tumor grade.
[Heliyon] |
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| The authors investigated the mechanism by which long noncoding RNA GHET1 promoted prostate cancer cell proliferation and related metabolism.
[Journal of Biochemical and Molecular Toxicology] |
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| Researchers evaluated the effects of the brachydin B flavonoid on cell viability, proliferation, and migration/invasion of metastatic prostate cells cultured both as traditional 2D monolayers and 3D tumor spheroids in vitro.
[Toxicology Research] |
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| Scientists measured the expression levels of glycolysis and OXPHOS-related genes and performed spheroid forming, cell viability, and various glycolysis to investigate the Warburg effect and cancer stem cell-like characteristics in prostate cancer.
[Biology Open] |
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| Investigators summarize the pathophysiological mechanisms and available targeted therapies for clinically actionable markers in prostate cancer.
[Biomolecules & Biomedicine] |
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| Loma Linda University (LLU) School of Medicine researchers received over $5.8 million in grants from the National Institutes of Health.
[Loma Linda University School of Medicine] |
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| May 1 – 4, 2022
Riviera Maya, Mexico |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The University of Miami – Miami, Florida, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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