 | | Vol. 14.15 – 28 April, 2023 |
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| Researchers reported that androgen receptor signaling pathway was evidently activated in tumor-associated macrophages of prostate cancer both in mice and humans.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By m6A-sequencing of patient cancer tissues, scientists identified that the overall level of m6A in CRPC was up-regulated than castration sensitive prostate cancer.
[Cell Death & Disease] |
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| In prostate OncoMice, prostate-specific deletion of the Dach1 gene enhanced prostatic intraepithelial neoplasia, and was associated with increased transforming growth factor β activity and DNA damage.
[Oncogene] |
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| Mouse models, in vitro human prostate cancer (PCa) cell lines, and human patient-derived organoids were used to study the expression and activity of isocitrate dehydrogenase enzymes in the normal prostate and PCa.
[Molecular Oncology] |
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| Researchers found that circARHGEF28 was frequently downregulated in prostate cancer (PCa) tissues and cell lines. Gain- and loss-of function experiments in vitro showed that circARHGEF28 inhibited proliferation, migration, and invasion of PCa.
[Cancer Science] |
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| Investigators explored several signaling pathways both in vitro using a prostate epithelial cell line and in vivo from the rat prostate model.
[Molecular Imaging and Biology] |
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| Scientists investigated the pro-inflammatory functions of the substance P (SP)/neurokinin receptor (NK‐1R) complex in prostate cancer and the therapeutic effects of its inhibition by NK‐1R antagonist, aprepitant, in vitro.
[Applied Biochemistry and Biotechnology] |
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| The authors explored the underlying mechanism of circDPP4 in prostate cancer (PCa) progression. They assessed the roles of variables in PCa cell phenotypes by measuring cell growth, apoptosis, motility, and invasiveness.
[Molecular Biotechnology] |
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| Investigators showed a high increase in DEAD-box helicase 49 (DDX49) in prostate cancer (PCa) tissues in comparison with normal tissues and that increased DDX49 indicated a poor prognosis among PCa patients.
[BMC Urology] |
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| The authors discuss the critical role of basal cells in the development and maintenance of healthy prostate tissue. Furthermore, they provide evidence supporting the role of basal cells in oncogenesis and therapeutic resistance mechanisms of prostate cancer.
[Cell Cycle] |
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| The $4-million endowed chair, funded in partnership with Western and London Health Sciences Foundation, will focus on driving innovation in research and transforming how cancers of the urinary tract and the male reproductive system are diagnosed and treated.
[Western University] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | University of Miami Desai Sethi Urology Institute – Miami, Florida, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | The University of Miami – Miami, Florida, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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