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| Scientists established 35 Chinese prostate cancer (PCa) primary cell models to capture specific characteristics among PCa patients, including gene mutations, mRNA/protein/surface protein distributions, and pharmaceutical responses.
[Signal Transduction and Targeted Therapy] |
|
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|
 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified a unique cluster of cancer cells in prostate cancer bone metastases, which expressed myeloid cell markers and showed a significant change in pathways related to immune regulation and tumor progression.
[Journal of Hematology & Oncology] |
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| Investigators reported that neuropilin-2, which functioned as a vascular endothelial growth factor (VEGF) receptor on tumor cells, was an attractive target to activate antitumor immunity in prostate cancer.
[Science Translational Medicine] |
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| Scientists reported a combinatorial strategy to treat bone metastatic castrate-resistant prostate cancer using γδ-enriched chimeric antigen receptor (CAR) T cells and zoledronate.
[Science Advances] |
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| The authors reported that combined EZH2/HDAC inhibitors potently kill castration-resistant prostate cancers (CRPCs) and caused dramatic tumor regression in aggressive human and mouse CRPC models.
[PLOS Biology] |
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| Researchers identified a novel circular RNA, circEPHA3, which was down-regulated in high-grade prostate cancer tissues and cell lines.
[Journal of Translational Medicine] |
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| Scientists studied mRNA levels and prognostic impact of all 15 human kallikrein-related peptidases and their targets, proteinase-activated receptors, in surgically treated prostate cancer.
[International Journal of Cancer] |
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| The authors performed RNA-sequencing to compare the mRNA expression profiles of seven localized prostate cancer (PCa) tissues and six metastatic PCa tissues. Spalt-like transcription factor 4 (SALL4) was then identified and compared in the localized PCa and metastatic PCa.
[Cancer Medicine] |
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| Investigators showed that toll-like receptor 5 (TLR5), among other TLRs, was exceedingly expressed in human prostate cancer cells. TLR5 functioned to activate the TLR5 signaling pathway in human prostate cancer cells
[The Prostate] |
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| Scientists discuss nonimmune components and various immune cells within the tumor microenvironment and their putative roles during prostate cancer initiation, progression, and metastasis.
[Molecular Therapy Oncolytics] |
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| Mid North Coast Cancer Institute (MNCCI) announced that Shearwater Lodge has provided a $150,000 grant. Prostate cancer patients at MNCCI will be the first in regional New South Wales to have access to a new type of treatment that dramatically reduces treatment time and waiting lists.
[Mid North Coast Local Health District] |
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| May 28 – 31, 2023
Killarney, Ireland |
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|
|
| | The Brady Urological Institute – Baltimore, Maryland, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | University of Miami Desai Sethi Urology Institute – Miami, Florida, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | The University of Miami – Miami, Florida, United States |
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