Prostate Cell News Volume 14.19 | May 26 2023

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    2023-05-26 | PCN 14.19


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.19 – 26 May, 2023
    TOP STORY

    Targeting PHB1 to Inhibit Castration-Resistant Prostate Cancer Progression In Vitro and In Vivo

    The biological roles of prohibitin (PHB1) in castration resistance and underlying mechanisms were investigated by gain/loss-of-function analyses. PHB1 expression was significantly upregulated in CRPC and was associated with poor prognosis.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    A Catalase Inhibitor: Targeting the NADPH-Binding Site for Castration-Resistant Prostate Cancer Therapy

    BT-Br, a NADPH-binding site inhibitor of catalase, was demonstrated to induce ferroptosis in CRPC DU145 cells and eventually reduce CRPC tumors in vivo effectively.
    [Redox Biology]

    Full Article

    Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

    In vitro cell experiments showed that the strengthened targeting ability of a new surface molecularly imprinted polymer, ZIF-8/DOX-HA@MIP, to prostate cancer cells was realized through the synergistic effect of hyaluronic acid and the molecularly imprinted membrane.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    CSNK1D-Mediated Phosphorylation of HNRNPA2B1 Induces miR-25-3p/miR-93-5p Maturation to Promote Prostate Cancer Cell Proliferation and Migration through m6A-Dependent Manner

    Investigators proved that heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) promoted the progression of prostate cancer through in vitro and in vivo experiments.
    [Cellular and Molecular Life Sciences]

    Abstract

    ScRNA-Seq Revealed an Immunosuppression State and Tumor Microenvironment Heterogeneity Related to Lymph Node Metastasis in Prostate Cancer

    Researchers explored the mechanism of lymph node metastasis by analyzing the heterogeneity of tumor microenvironment in prostate cancer using scRNA-seq.
    [Experimental Hematology & Oncology]

    Full Article

    Investigation on the Mechanisms by Which the Herbal Remedies Induce Anti-Prostate Cancer Activity: Uncovering the Most Practical Natural Compound

    The authors evaluated the anti-prostate cancer activity of traditional and herbal remedies, revealing PTEN’s role in suppressing prostate cancer cells via its phosphatase activity.
    [Journal Of Biomolecular Structure & Dynamics]

    Abstract

    Proapoptotic Effect of Nonthermal Pulsed Ultrasound on Prostate Cancer Cells in a Nude Mouse Model

    Scientists evaluated postirradiation cells immediately after pulse repetition frequency treatment and examined membrane disruption by proliferation assay, LDH assay, and apoptosis assay.
    [The Prostate]

    Abstract

    A Novel Co-Culture Model of Human Prostate Epithelial and Stromal Cells for Androgenic and Antiandrogenic Screening

    Investigators built a prostate epithelial and stromal co-culture microtissue model with BHPrE and BHPrS cells in scaffold-free hydrogels.
    [Toxicology In Vitro]

    Abstract

    7-Geranyloxcycoumarin Enhances Radio Sensitivity in Human Prostate Cancer Cells

    To improve radiotherapy outcome, the authors investigated the effects of 7-geranyloxycoumarin, also known as auraptene, on radiation response of prostate cancer cells.
    [Molecular Biology Reports]

    Abstract
    Learn how to stay motivated in research.
    REVIEWS

    Melatonin and Prostate Cancer: Anti-Tumor Roles and Therapeutic Application

    Scientists expand on the important epidemiological evidence and review how melatonin can impede prostate cancer describing the currently known mechanisms of melatonin-mediated oncostasis in prostate cancer.
    [Aging and Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    Voelcker Fund Award Supports Innovative Research

    The University of Texas (UT) Health San Antonio has announced that the Max and Minnie Tomerlin Voelcker Fund is awarding $1.8 million to UT Health San Antonio to support research projects conducted by promising early career researchers.
    [UT Health San Antonio]

    Press Release
    FEATURED EVENT

    Single Cell Biology: From Development to Cancer

    June 18 – 22, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Prostate Immunology

    Eastern Virginia Medical School – Norfolk, Virginia, United States

    Postdoctoral Fellow – Cancer Research

    Georgia Cancer Center at Augusta University – Augusta, Georgia, United States

    Postdoctoral Fellows – Prostate Cancer Genetics and Genomics

    The Brady Urological Institute – Baltimore, Maryland, United States

    Postdoctoral Fellow – Prostate Cancer Research

    University of Miami Desai Sethi Urology Institute – Miami, Florida, United States

    Research Assistant – Lipidomic Dependencies of Cancer

    Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States

    > See All Jobs

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