Prostate Cell News Volume 14.23 | Jun 23 2023

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    2023-06-23 | PCN 14.23


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.23 – 23 June, 2023
    TOP STORY

    Antiandrogen Treatment Induces Stromal Cell Reprogramming to Promote Castration Resistance in Prostate Cancer

    Researchers showed that androgen deprivation therapy-induced SPP1+ myofibroblastic cancer-associated fibroblasts were critical stromal constituents that drove the development of CRPC.
    [Cancer Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Chemokine Receptor CXCR7 Activates AURKA and Promotes Neuroendocrine Prostate Cancer Growth

    The authors reported that CXCR7 was elevated in the majority of prostate cancer with neuroendocrine features. CXCR7 markedly induced mitotic spindle and cell cycle gene expression.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    A Phase Ib, Open-Label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer

    Ipatasertib plus rucaparib was manageable with dose modification but did not demonstrate synergistic or additive antitumor activity in previously treated patients with metastatic CRPC.
    [Clinical Cancer Research]

    Abstract

    Novel Bioactive Cationic Cubosomes Enhance the Cytotoxic Effect of Paclitaxel against a Paclitaxel Resistant Prostate Cancer Cell-Line

    Scientists used molecular hybridization of a cationic lipid with a known pharmacophore to produce a bifunctional lipid having a cationic charge to enhance fusion with the cancer cell surface and biological activity.
    [Journal of Colloid and Interface Science]

    AbstractGraphical Abstract

    ASCL1-Mediated Ferroptosis Resistance Enhances the Progress of Castration-Resistant Prostate Cancer to Neurosecretory Prostate Cancer

    The authors revealed that ASCL1 was regulated by the SRY-box transcription factor 2 and highly expressed in neuroendocrine prostate cancer cells, which was closely related to poor prognosis.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract

    ATXN3 Promotes Prostate Cancer Progression by Stabilizing YAP

    Investigators identified ATXN3, a DUB enzyme in the ubiquitin-specific proteases family, as a bona fide deubiquitylase of YAP in prostate cancer.
    [Cell Communication and Signaling]

    Full Article

    Androgen Receptor Knockdown Enhances Prostate Cancer Chemosensitivity by Down-Regulating FEN1 through the ERK/ELK1 Signaling Pathway

    Researchers demonstrated that androgen receptor knockdown improved the docetaxel sensitivity of prostate cancer cells by downregulating flap endonuclease 1 (FEN1) through the ERK/ELK1 signaling pathway.
    [Cancer Medicine]

    Full Article

    Fibroblast-Derived Exosomal microRNA Regulates NKX3-1 Expression in Androgen-Sensitive, Androgen Receptor-Dependent Prostate Cancer Cells

    Scientists investigated the effects of normal fibroblasts and three prostate cancer (PCa) patient-derived fibroblast lines on the expression of cancer-related genes in androgen-sensitive, LNCaP cells, and three sublines showing different androgen sensitivities and androgen receptor dependencies.
    [Journal of Cellular Biochemistry]

    Full Article

    Targeting Prostate Cancer with Docetaxel-Loaded Peptide 563-Conjugated PEtOx-Co-PEI30%-B-PCL Polymeric Micelle Nanocarriers

    Investigators aimed to assess the in vitro and in vivo targeting efficiency, safety, and efficacy of P563-conjugated, docetaxel-loaded polymeric micelle nanoparticles against prostate cancer.
    [Amino Acids]

    Abstract

    Screening and Validation of Novel Serum Panel of microRNA in Stratification of Prostate Cancer

    Scientists demonstrated the precision of a panel of miRNAs as biomarkers with diagnostic potential for risk stratification of prostate cancer.
    [Prostate International]

    Full Article
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    REVIEWS

    ELAC2 Is a Functional Prostate Cancer Risk Allele

    The authors unveil the functional role of a human germline mutation found in the ribonuclease Z enzyme, ELAC2, in prostate cancer.
    [Trends In Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Novel Prostate Cancer Therapy Receives FDA Approval

    Neeraj Agarwal, MD, FASCO, Presidential Endowed Chair of Cancer Research at Huntsman Cancer Institute, received approval from the US FDA for a new prostate cancer treatment.
    [University of Utah Health]

    Press Release
    FEATURED EVENT

    Molecular Analysis for Precision Oncology Congress 2023

    October 4 – 6, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Prostate Cancer Metastasis

    Cedars Sinai Medical Center – Los Angeles, California, United States

    Senior Research Impact Officer – Prostate Cancer

    Prostate Cancer UK – London, England, United Kingdom

    Postdoctoral Fellow – Cancer Biology

    City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Genitourinary Medical Oncology Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Research

    Georgia Cancer Center at Augusta University – Augusta, Georgia, United States

    > See All Jobs

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