| Vol. 14.23 – 23 June, 2023 |
| |
|
|
| Researchers showed that androgen deprivation therapy-induced SPP1+ myofibroblastic cancer-associated fibroblasts were critical stromal constituents that drove the development of CRPC. [Cancer Cell] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors reported that CXCR7 was elevated in the majority of prostate cancer with neuroendocrine features. CXCR7 markedly induced mitotic spindle and cell cycle gene expression. [Journal of Clinical Investigation] |
|
|
|
| Ipatasertib plus rucaparib was manageable with dose modification but did not demonstrate synergistic or additive antitumor activity in previously treated patients with metastatic CRPC. [Clinical Cancer Research] |
|
|
|
| Scientists used molecular hybridization of a cationic lipid with a known pharmacophore to produce a bifunctional lipid having a cationic charge to enhance fusion with the cancer cell surface and biological activity. [Journal of Colloid and Interface Science] |
|
|
|
| The authors revealed that ASCL1 was regulated by the SRY-box transcription factor 2 and highly expressed in neuroendocrine prostate cancer cells, which was closely related to poor prognosis. [Free Radical Biology and Medicine] |
|
|
|
| Investigators identified ATXN3, a DUB enzyme in the ubiquitin-specific proteases family, as a bona fide deubiquitylase of YAP in prostate cancer. [Cell Communication and Signaling] |
|
|
|
| Researchers demonstrated that androgen receptor knockdown improved the docetaxel sensitivity of prostate cancer cells by downregulating flap endonuclease 1 (FEN1) through the ERK/ELK1 signaling pathway. [Cancer Medicine] |
|
|
|
| Scientists investigated the effects of normal fibroblasts and three prostate cancer (PCa) patient-derived fibroblast lines on the expression of cancer-related genes in androgen-sensitive, LNCaP cells, and three sublines showing different androgen sensitivities and androgen receptor dependencies. [Journal of Cellular Biochemistry] |
|
|
|
| Investigators aimed to assess the in vitro and in vivo targeting efficiency, safety, and efficacy of P563-conjugated, docetaxel-loaded polymeric micelle nanoparticles against prostate cancer. [Amino Acids] |
|
|
|
| Scientists demonstrated the precision of a panel of miRNAs as biomarkers with diagnostic potential for risk stratification of prostate cancer. [Prostate International] |
|
|
|
|
| The authors unveil the functional role of a human germline mutation found in the ribonuclease Z enzyme, ELAC2, in prostate cancer. [Trends In Molecular Medicine] |
|
|
|
|
| Neeraj Agarwal, MD, FASCO, Presidential Endowed Chair of Cancer Research at Huntsman Cancer Institute, received approval from the US FDA for a new prostate cancer treatment. [University of Utah Health] |
|
|
|
|
| October 4 – 6, 2023 Paris, France |
|
|
|
|
|
| Cedars Sinai Medical Center – Los Angeles, California, United States |
|
|
|
| Prostate Cancer UK – London, England, United Kingdom |
|
|
|
| City of Hope – Duarte, California, United States |
|
|
|
| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| Georgia Cancer Center at Augusta University – Augusta, Georgia, United States |
|
|
|
|