 | | Vol. 14.25 – 7 July, 2023 |
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| Investigators showed that stromal cell-derived small extracellular vesicles (sEVs) facilitated the radioresistance of prostate cancer (PCa) cells by transporting interleukin-8 (IL-8). Prostatic stromal cells secreted more IL-8 than AR-positive PCa cells, which could be accumulated in sEVs.
[Journal of Extracellular Vesicles] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors performed a signaling pathway-guided splicing analysis to identify MYC-dependent splicing events. These included an HRAS cassette exon repressed by MYC across multiple tumor types.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists explored a therapeutic strategy for prostate cancer based on the ability of sh/siRNAs to function essentially as miRNAs and, via seed sequence complementarity, induce RNA interference of numerous targets simultaneously.
[Molecular Therapy – Nucleic Acids] |
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| To determine whether the combination of cytotopically modified interleukin-15 (cyto-IL-15) with the stimulator of interferon genes (STING) agonist, ADU-S100 could lead to both local and systemic anti-tumor effects, intratumoral administration of these agents was used in murine models of prostate cancer.
[Frontiers in Immunology] |
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| Researchers showed that C7 was specifically expressed by the stromal cells in both mouse and human prostates. The expression level of C7 inversely correlated with clinical outcomes in prostate cancer.
[Oncogene] |
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| The expression of Bloom’s syndrome protein (BLM) in human specimens was analyzed using immnohistochemistry. A 5′-biotin-labeled DNA probe containing the promoter region of BLM was synthesized to pull down BLM promoter-binding proteins.
[Journal of Translational Medicine] |
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| In a co-culture of osteoblasts (OBs) and osteoblastic prostate cancer (BPCa) cells, SERPINA3 and LCN2 were remarkably upregulated in BPCa via OB-derived extracellular vesicles, while they were not in the co-culture of OBs and osteolytic prostate cancer cells.
[Molecular Oncology] |
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| Scientists showed that hiPSCs can be differentiated into prostate organoids using neonatal rat seminal vesicle mesenchyme in vitro. The organoids can be used to study prostate development or modified to study prostate cancer.
[Development] |
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| Curcumin-loaded solid lipid nanoparticles were prepared, and morphology, particle size, and entrapment efficiency were studied.
[ACS Applied Bio Materials] |
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| Scientists carry out a narrative synthesis of various molecular profiles related to their clinical context and analyze current guidelines for genetic testing and its feasibility in clinical practice.
[BJU International] |
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| The authors provide an overview of the immune response, tumor microenvironment, and present level and future trends of expanding prostate cancer immunotherapy.
[International Journal of Peptide Research and Therapeutics] |
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| Men with prostate cancer who formed an advocacy group for a noninvasive treatment strategy for managing low-risk cancers are recognizing Dr. Peter Albertsen as one of their champions.
[University of Connecticut] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | University of Miami – Miami, Florida, United States |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | BC Cancer Center – Vancouver, British Columbia, Canada |
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| | Prostate Cancer UK – London, England, United Kingdom |
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| | Georgia Cancer Center at Augusta University – Augusta, Georgia, United States |
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