 | | Vol. 14.27 – 21 July, 2023 |
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| The authors identified synaptotagmin-binding cytoplasmic RNA-interacting protein (SYNCRIP) as an endogenous molecular brake that suppressed APOBEC-driven mutagenesis in prostate cancer.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that FTO-IT1 long noncoding RNA (lncRNA) was upregulated and positively correlated with poor survival of patients with wild-type p53-expressing prostate cancer.
[Molecular Cell] |
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| Scientists analyzed 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays.
[Nature Communications] |
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| Investigators showed that spermine inhibited full-length androgen receptor (AR) and androgen receptor splice variant 7 signaling and suppressed castration-resistant prostate cancer cell proliferation by directly binding and inhibiting protein arginine methyltransferase protein arginine methyltransferases (PRMT) 1.
[Cell Reports] |
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| Scientists determined that lysine-specific demethylase 1 (LSD1) was highly upregulated in neuroendocrine prostate cancer (NEPC) vs. adenocarcinoma patient tumors. LSD1 suppression with RNAi or allosteric LSD1 inhibitors—but not catalytic inhibitors—reduced NEPC cell survival.
[JCI Insight] |
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| The authors performed a longitudinal study using their unique prostate cancer patient-derived xenograft models and assessed B7-H3 expression during post-androgen deprivation therapy (ADT) disease progression.
[Cancer Gene Therapy] |
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| Using the human prostate cancer cell line C4-2, investigators found that epidermal growth factor (EGF)-activated EGFR–ERK1/2 signaling via 3-O-sulfated heparan sulfate produced by HS 3-O-sulfotransferase 1 is activated in C4-2 cells under hormone depletion.
[Scientific Reports] |
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| Researchers developed a microphysiological system model comprising conventional prostate cancer cells to evaluate their activity under dynamic culture conditions. Androgen-sensitive and androgen-insensitive cells were grown in conventional and 3D cultures, both static and dynamic.
[Scientific Reports] |
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| Methyltransferase-like 3 (METTL3), miR-148a-3p, and thioredoxin interacting protein (TXNIP) levels were determined using RT-qPCR and Western blotting. The m6A modification level of miR-148a-3p was observed by Me-RIP assay.
[Environmental Toxicology] |
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| Scientists highlight the current in vitro 3D prostate cancer (PCa) models with a special focus on organoids and discuss engineering approaches to create more physiologically relevant PCa organoid models.
[Oncogene] |
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| The authors summarize the definition and classification of oligometastatic prostate cancer, assess the diagnostic methods and imaging modalities utilized, and review the treatment options and outcomes.
[Prostate Cancer and Prostatic Diseases] |
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| Ambrx Biopharma Inc. announced that the U.S. FDA has granted Fast Track designation to Ambrx’s proprietary anti-PSMA antibody-drug conjugate investigational therapy, ARX517, for the treatment of patients with metastatic castration-resistant prostate cancer.
[Ambrx Biopharma Inc.] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | Moffitt Cancer Center – Tampa, Florida, United States |
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| | Washington University – St. Louis, Missouri, United States |
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| | Albert Einstein College of Medicine – New York City, New York, United States |
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| | University of Miami – Miami, Florida, United States |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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