 | | Vol. 14.29 – 4 August, 2023 |
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| Investigators showed that the transfer RNA N7-methylguanosine transferase METTL1 was highly expressed in primary and advanced prostate tumors.
[Molecular Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that TMPRSS2-ERG fusion and TP53 mutation/deletion co-occur in prostate cancer patient specimens and this co-occurrence accelerates prostatic oncogenesis.
[Nature Communications] |
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| Scientists demonstrated that acute treatment with the antiandrogen enzalutamide decreased glutathione production, increased lipid peroxidation, and induced ferroptosis in prostate cancer cells.
[Cancer Research] |
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| Assessment of the invasive potential of cells and senescence status following enzalutamide treatment and/or RNAi-mediated silencing of selected targets was performed in all cell lines, complemented by bioinformatics analyses on a wide range of in vitro and in vivo datasets.
[Journal Of Experimental & Clinical Cancer Research] |
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| Scientists found that squalene epoxidase (SQLE) was a crucial mediator of cholesterol metabolism in prostate cancer growth. They observed a profound upregulation of SQLE in prostate cancer tissues, and its high expression was correlated with poor patient outcomes.
[Cell Death & Disease] |
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| Researchers highlighted novel molecular pathways for targeting cellular pyroptosis and enhancing the effectiveness of anti-PD1-based immunotherapy. Prostate cancer cell lines were evaluated via the next-generation RNA sequencing to assess transcriptomic profile upon CDC20 depletion.
[Experimental Hematology & Oncology] |
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| Scientists studied the effect of exosomes isolated from the serum of patients with prostate cancer (PCa) on various cellular processes associated with increased tumor aggressiveness in two PCa cell lines: LNCaP-FGC and PC3.
[International Journal Of Cancer] |
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| Investigators demonstrated that the expression of CDC20 was increased in prostate cancer (PCa) cells by irradiation, and knockdown of CDC20 resulted in inhibition of cell proliferation, migration, tumor formation, induced cell apoptosis, and increased radiosensitivity in PCa in vitro and in vivo.
[Apoptosis] |
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| Researchers overexpressed N-cadherin in LNCaP cells and downregulated N-cadherin in PC3 cells by lentiviral transduction. Then, differentially expressed genes and dysregulated biological functions were investigated through RNA sequencing analyses.
[DNA And Cell Biology] |
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| The authors provide an overview of kinases that are impacted by gene amplification, gene deletion, or somatic mutations during the progression from localized treatment-naïve prostate cancer (CaP) to metastatic castration-resistant CaP or neuroendocrine CaP.
[Endocrine-Related Cancer] |
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| Dr. Tanya Stoyanova was awarded a $1.5 million grant from the National Cancer Institute to identify new treatment strategies for neuroendocrine prostate cancer. The grant will help support Stoyanova and her team identify new molecular mechanisms underlying the development of neuroendocrine prostate cancer.
[UCLA Health] |
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| September 6 – 8, 2023
Hinxton, England, United Kingdom |
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| | The University of Iowa – Iowa City, Iowa, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Debiopharm – Lausanne, Switzerland |
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| | IRB Barcelona – Barcelona, Spain |
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| | Washington University – St. Louis, Missouri, United States |
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