Prostate Cell News Volume 14.35 | Sep 15 2023

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    2023-09-15 | PCN 14.35


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.35 – 15 September, 2023
    TOP STORY

    Transposable Elements Are Co-Opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer

    Using chromatin editing technology, scientists showed how such elements promote prostate cancer growth by regulating AR transcriptional activity.
    [Cancer Discovery]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    YAP Is Required for Prostate Development, Regeneration, and Prostate Stem Cell Function

    Investigators explored the roles of Yes-associated protein 1 (YAP) in prostate stem cells, prostate development and regeneration.
    [Cell Death Discovery]

    Full Article

    The SGLT2 Inhibitor Canagliflozin Suppresses Growth and Enhances Prostate Cancer Response to Radiotherapy

    Scientists showed that well-tolerated doses of canagliflozin suppressed proliferation and survival of androgen-sensitive and insensitive human prostate cancer cells and tumors and sensitized them to radiotherapy.
    [Communications Biology]

    Full Article

    Expression of microRNA-379 Reduces Metastatic Spread of Prostate Cancer

    Prostate cancer cells with increased levels of miR-379 showed a significant decrease in proliferation, migration, colony formation, and adhesion to bone cells in vitro.
    [Frontiers in Oncology]

    Full Article

    Dominant Negative TGFβ Receptor II and Truncated TIM3 Enhance the Antitumor Efficacy of CAR-T-Cell Therapy in Prostate Cancer

    Researchers attempted to improve the tumor killing capability of prostate-specific membrane antigen-chimeric antigen receptor T (CAR-T) cells by targeting T cell immunoglobulin and mucin domain 3 (TIM3) and transforming growth factor beta (TGFβ) receptor II simultaneously.
    [International Immunopharmacology]

    Full Article

    The Active Phthalate Metabolite, DHEP, Induces Proliferation and Metastasis of Prostate Cancer Cells via Upregulation of β-Catenin and Downregulation of KLF7: Effects of DHEP on Prostate Cancer Cells

    Scientists demonstrated the potential of DHEP in increasing the tumorigenic properties of DU145 cells along with a focus on the underlying mechanisms.
    [Bioorganic Chemistry]

    AbstractGraphical Abstract

    Cannabidiol Inhibits the Proliferation and Invasiveness of Prostate Cancer Cells

    The authors investigated the antiproliferative and anti-invasive properties of cannabidiol (CBD) in prostate cancer cells in vitro. CBD inhibited cell viability and proliferation, accompanied by reduced expression of key cell cycle proteins.
    [Journal Of Natural Products]

    Full ArticleGraphical Abstract

    Distinct Patterns of Biomarker Expression for Atypical Intraductal Proliferations in Prostate Cancer

    A panel of biomarkers was assessed to provide insights into the biological relationship between intraductal carcinoma of the prostate, high-grade prostatic intraepithelial neoplasia, and atypical intraductal proliferations and their relevance to current clinicopathological recommendations.
    [Virchows Archiv]

    Full Article

    TNS1 Regulated by HLF Represses the Progression of Prostate Cancer

    Researchers investigated the function of hepatic leukemia factor (HLF) in prostate cancer and its relation to tensin 1 (TNS1). DU145 and PC3 cells overexpressing HLF were established.
    [Mutagenesis]

    Abstract
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    REVIEWS

    Targeting Sex Steroid Biosynthesis for Breast and Prostate Cancer Therapy

    The authors specifically summarize the approaches so far applied to inhibit estrogen and androgen availability for receptor binding via inhibiting steroid biosynthesis.
    [Nature Reviews Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Possible Misconduct Found in Papers from Italian Minister of Health

    An Italian newspaper has found duplicated images in eight cancer papers co-authored by the country’s minister of health, Orazio Schillaci. Dr. Schillaci published the papers between 2018 and 2022 while working in the faculty of medicine of the University of Rome Tor Vergata.
    [Science Insider]

    Press Release
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    JOB OPPORTUNITIES

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    Cedars-Sinai – Los Angeles, California, United States

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    Cedars-Sinai – Los Angeles, California, United States

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