Prostate Cell News Volume 14.36 | Sep 22 2023

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    2023-09-22 | PCN 14.36


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.36 – 22 September, 2023
    TOP STORY

    Suppression of Tumor Cell Lactate-Generating Signaling Pathways Eradicates Murine PTEN/p53-Deficient Aggressive-Variant Prostate Cancer via Macrophage Phagocytosis

    Scientists targeted immunometabolic mechanisms of PI3Ki resistance, with the goal of durable tumor control in aggressive-variant prostate cancer.
    [Clinical Cancer Research]

    Abstract
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Reciprocal Negative Feedback Regulation of ATF6α and PTEN Promotes Prostate Cancer Progression

    The authors demonstrated that the expression level of phosphatase and tensin homolog (PTEN) was inversely correlated with the signature score of unfolded protein response in prostate cancer.
    [Cellular and Molecular Life Sciences]

    Abstract

    RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer

    Researchers developed an RNA interference method against adenosine triphosphate (ATP) by constructing an interfering plasmid-expressing ATP-binding RNA aptamer, which notably inhibited the growth of prostate cancer cells through diminishing the availability of cytoplasmic ATP.
    [Molecular Pharmaceutics]

    AbstractGraphical Abstract

    Selenium in Combination with a Tomato Lipid Extract as a Therapy for Benign Prostatic Hyperplasia and Its Alterations in Rats with Induced BPH

    The authors evaluated the therapeutic effect of selenium in combination with a tomato extract in aged rats with benign prostatic hyperplasia (BPH).
    [Journal of Cellular and Molecular Medicine]

    Full Article

    The Effect of Acupuncture on Estrogen Receptors in Rats with Benign Prostatic Hyperplasia

    Scientists elucidated the effects of acupuncture on the protein and gene expression of estrogen receptors alpha and beta in testosterone-induced benign prostatic hyperplasia in rat models.
    [Journal of Steroid Biochemistry and Molecular Biology]

    Full ArticleGraphical Abstract

    Tumor-Microenvironment Responsive Nano-Carrier System for Therapy of Prostate Cancer

    Experiments in vitro showed that DTX-loaded poly-Tetraethylene glycol nanoparticles had good compatibility to healthy cells and strong anti-tumor effect.
    [Journal Of Materials Science-Materials In Medicine]

    Full ArticleGraphical Abstract

    Doxorubicin-Induced Senescence Promotes Resistance to Cell Death by Modulating Genes Associated with Apoptotic and Necrotic Pathways in Prostate Cancer DU145 CD133+/CD44+ Cells

    Investigators elucidated the effects of senescence induction on proliferation, cell cycle, and apoptosis in prostate cancer stem cells (CSCs) and non-CSCs.
    [Biochemical and Biophysical Research Communications]

    AbstractGraphical Abstract

    A Crosstalk between Castration-Resistant Prostate Cancer Cells, M2 Macrophages, and NK Cells: Role of the ATM-PI3K/AKT-PD-L1 Pathway

    Using CRPC cell lines, the transwell chamber experiments revealed ataxia telangiectasia mutant kinase (ATM) promoted macrophage recruitment in CRPC cells in vitro via C-X-C motif chemokine ligand 12.
    [Immunological Investigations]

    Full Article

    Knocking Down SOX2 Overcomes the Resistance of Prostate Cancer to Castration via Notch Signaling

    Researchers aimed to clarify the regulatory roles of the SOX2/Notch axis in CRPC. They conducted immunohistochemistry analyses to evaluate SOX2, Notch, and Hey1 expression in the prostate cancer and CRPC tissues.
    [Molecular Biology Reports]

    Abstract
    A person presenting slides at a scientific conference
    REVIEWS

    Prostate Cancer Immunotherapy: Improving Clinical Outcomes with a Multi-Pronged Approach

    Scientists provide a summary of the status of immunotherapy in treating prostate cancer, with a discussion of multiple immune modalities, including vaccines, adoptively transferred T cells, and bispecific T cell engagers.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Recent Insights on the Clinical, Pathological, and Molecular Features of Intraductal Carcinoma of the Prostate

    Investigators summarize and outline the clinical and pathological features, differential diagnosis, molecular aspects, and management of intraductal carcinoma of the prostate, as described in previous studies.
    [International Journal Of Urology]

    Full Article
    INDUSTRY AND POLICY NEWS

    £1 Million Funding Award Supports Leading New Medical Research at Northumbria University

    Two renowned biomedical researchers have been awarded £1 million to undertake world-leading research into diseases such as prostate cancer and mitochondrial disease at Northumbria University.
    [Northumbria University]

    Press Release
    FEATURED EVENT

    The Tumor Landscape: Translating Mechanism to Therapy

    October 29 – November 1, 2023
    New York, New York, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Prostate Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – NMR-based Metabolomics and Metabolomic Imaging

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Faculty Positions – Cancer Research

    Houston Methodist Research Institute – Houston, Texas, United States

    Faculty Positions – Cancer Metastasis

    The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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