Prostate Cell News Volume 14.37 | Sep 29 2023

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    2023-09-29 | PCN 14.37


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.37 – 29 September, 2023
    TOP STORY

    The Catalytic Subunit of DNA-PK Regulates Transcription and Splicing of AR in Advanced Prostate Cancer

    Researchers demonstrated that the DNA-PK holoenzyme was part of the androgen receptor variant 7 (AR-V7) interactome and was a key regulator of AR-V-mediated transcription and cell growth in models of advanced prostate cancer.
    [Journal of Clinical Investigation]

    Abstract
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    Light-Responsive Smart Nanocarriers for Wirelessly Controlled Photodynamic Therapy for Prostate Cancers

    The combination of smart nanocarrier and sequential ‘405-580 nm’ irradiation strategy exhibited good photodynamic therapy efficacy against 2D 22RV1 prostate cancer cells as well as 3D cancer cell spheroids.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    Loss of PDE4D7 Expression Promotes Androgen Independence, Neuroendocrine Differentiation, and Alterations in DNA Repair: Implications for Therapeutic Strategies

    Using shRNA-mediated PDE4D7 knockdown in LNCaP cells, scientists replicated clinical observations that diminished PDE4D7 expression promoted an aggressive prostate cancer phenotype.
    [British Journal of Cancer]

    Full Article

    m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

    Investigators found that circular RNA DDIT4 (circDDIT4) was downregulated in prostate cancer and functioned as a tumor suppressor during prostate cancer progression.
    [Molecular Cancer Research]

    Abstract

    Development and Characterization of Suitably Bioengineered Microfibrillar Matrix-Based 3D Prostate Cancer Model for In Vitro Drug Testing

    Microfibrillar matrices were fabricated as 3D spherical and disc-shaped scaffolds with highly interconnected pores and the potential of the newly developed scaffolds for developing prostate cancer model has been investigated.
    [Biomedical Materials]

    Abstract

    Polyphyllin I Induces Ferroptosis in Castration-Resistant Prostate Cancer Cells through the ERK/DNMT1/ACSL4 Axis

    Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been shown to have an anticancer effect. Researchers investigated the role and mechanism of PPI in CRPC cell ferroptosis.
    [The Prostate]

    Abstract

    Docetaxel Radiosensitizes Castration Resistant Prostate Cancer by Downregulating CAV-1

    The authors investigated the effectiveness and molecular characteristics of docetaxel and radiation combination therapy in vitro.
    [International Journal of Radiation Biology]

    Abstract

    Sennoside a Induces Autophagic Death of Prostate Cancer via Inactivation of PI3K/AKT/mTOR Axis

    Investigators detected the toxicity of sennoside A (SA) on PC3 and DU 145 cells via CCK-8. The effects of SA on growth, apoptosis, and autophagy were determined through additional examinations.
    [Journal of Molecular Histology]

    Abstract

    miR-199a/214 Cluster Enhances Prostate Cancer Sensitiveness to Nimotuzumab via Targeting TBL1XR1

    To investigate the molecular mechanisms underlying the effects of nimotuzumab on prostate cancer development, the authors focused on the miR-199a-5p and miR-214-3p miRNA clusters.
    [Kaohsiung Journal Of Medical Sciences]

    Full Article

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    REVIEWS

    Epithelial Specific Splicing Regulator Proteins as Emerging Oncogenes in Aggressive Prostate Cancer

    Scientists discuss how expression of the splicing regulators ESRP1 and ESRP2, and how their role as “masterminds” of epithelial splicing patterns, have been identified as markers of aggressively proliferating prostate primary tumors.
    [Oncogene]

    Full Article
    INDUSTRY AND POLICY NEWS

    Profound Medical Receives US FDA 510(k) Clearance for TULSA-PRO® Thermal Boost

    Profound Medical Corp. announced that it has received 510(k) clearance from the US FDA for the Company’s Thermal Boost module for use in conjunction with TULSA-PRO®.
    [Profound Medical Corp. (Globe Newswire)]

    Press Release
    FEATURED EVENT

    Cell 2023

    November 7 – 8, 2023
    London, England, United Kingdom

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Translational Oncogenomics

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    Postdoctoral Research Fellow – Prostate Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – NMR-based Metabolomics and Metabolomic Imaging

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Faculty Positions – Cancer Research

    Houston Methodist Research Institute – Houston, Texas, United States

    Faculty Positions – Cancer Metastasis

    The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    > See All Jobs

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