 | | Vol. 14.40 – 20 October, 2023 |
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| Investigators showed that inhibition of myeloid chemotaxis could reduce tumor-elicited myeloid inflammation and reverse therapy resistance in a subset of metastatic CRPC patients.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists generated a radioresistant prostate cancer (PCa) cell line, and found p53 to be highly expressed in radioresistant PCa cells, as well as in PCa patients with recurrent/disease progression submitted to radiotherapy.
[Signal Transduction and Targeted Therapy] |
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| The authors found that tumor suppressor RNAs tended to decay fast in normal cell types when compared with other RNAs.
[Nucleic Acids Research] |
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| Researchers showed that upregulation of CDK13 in prostate cancer (PCa) cells increases the fatty acyl chains and lipid classes, leading to lipid deposition in the cells, which was positively correlated with the expression of acetyl-CoA carboxylase (ACC1).
[Cell Death & Differentiation] |
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| Investigators conducted an unbiased analysis of transcriptome data from large collections of prostate cancer samples and employed diverse in vitro and in vivo models.
[JNCI-Journal Of The National Cancer Institute] |
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| Scientists validated a HOXB13 antibody using genetic controls and investigated HOXB13 protein expression in murine and human developing prostates, localized prostate cancers, and mCRPCs.
[Journal of Pathology] |
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| Researchers identified the downregulation of HOXA5 in prostate cancer (PCa) tissues based on the TCGA database and further verified in 30-paired PCa and adjacent normal tissues.
[Cell Death Discovery] |
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| RNF185 was identified as novel marker for prostate cancer metastasis, through control of COL3A1 expression.
[Molecular Cancer Research] |
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| Researchers validated the modulator of volume-regulated anion channel current 1 (MLC1)’s anti-tumor effects and uncovered potential mechanisms. MLC1 expression was significantly reduced in prostate cancer samples compared with the adjacent normal tissues.
[Advanced Biology] |
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| Scientists introduce the ubiquitination process and E3 ubiquitin ligase, focusing on the recently discovered multiple mechanisms by which ubiquitination affects prostate cancer development and metastasis.
[Cell Biochemistry and Biophysics] |
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| Some advanced forms of prostate cancer find it is able to evade treatment by using their immune system to resist the impact of drugs. Now scientists have discovered a way to stop it being able to do this, opening up the possibility of treatments for men left with little hope.
[The Guardian] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Stanford University – Stanford, California, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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