 | | Vol. 14.41 – 27 October, 2023 |
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| Investigators explored the expression, function, and mechanism of AZGP1P2, a pseudogene of AZGP1, in regulating the stemness and apoptosis of prostate cancer stem cells and treatment resistance of docetaxel in castration-resistant prostate cancer.
[Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The expression of SETD4 in prostate cancer (PCa) cells and tissue samples was downregulated in PCa cells and tissue specimens, and decreased SETD4 expression led to inferior clinicopathological characteristics in patients with PCa.
[Cancer Letters] |
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| Androgen or antagonist’s cellular treatments and knockdown experiments were used to detect changes in cell morphology, molecular markers, migration properties, and in vivo tumor growth.
[British Journal Of Cancer] |
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| Using prostate cancer (PCa) cells isogenic for PTEN, researchers showed that PTEN-deficiency correlated with dependence on both p110β and AKT2 for in vitro and in vivo parameters of metastatic growth or motility, and with downregulation of SMAD4, a known PCa metastasis suppressor.
[Oncogene] |
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| Researchers showed that NPM1 was overexpressed in PCa cell lines and tissues and that the dysregulation of NPM1 promoted prostate cancer proliferation.
[Cell Death Discovery] |
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| Treatment-emergent adverse events for patients receiving darolutamide for a median of 38 months are described in this pooled analysis of individual patient data from Phase I/II studies.
[Prostate Cancer And Prostatic Diseases] |
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| A common drug against the human immunodeficiency virus (HIV), dolutegravir, was modified to become a series of dolutegravir-1,2,3-triazole derivatives.
[Bioorganic Chemistry] |
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| Researchers investigated the impact of separated distance at prostate-apex and of a modifier technique, on radiation exposure reduction during proton beam therapy.
[Scientific Reports] |
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| Overexpression of canonical MED19 in LNCaP cells promoted growth under conditions of androgen deprivation in vitro and in vivo, mirroring earlier findings with alternative MED19-overexpressing LNCaP cells.
[Scientific Reports] |
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| The authors treated PC-3 cells with 200µmol SAM, a concentration known to cause anticancerogenic effects, followed by ChIP-sequencing for H3K4me3 and H3K27me3.
[Gene] |
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| Researchers investigated the antitumor effect of berbamine, extracted from Berberis amurensis, on prostate cancer stem cells.
[The Prostate] |
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| Investigators outline precision medicine in metastatic castration-resistant prostate cancer, zooming in on the role of circulating tumor DNA, to identify genomic biomarkers that may be used to tailor molecularly targeted therapies.
[Critical Reviews In Clinical Laboratory Sciences] |
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| ONCT-534 interacts with both the N-terminal domain and the ligand-binding domain of the androgen receptor, inhibiting cell growth and inducing androgen receptor degradation.
[Oncternal Therapeutics, Inc.] |
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| The Prostate Cancer Foundation announced the Class of 2023 Young Investigator Award recipients totaling $6.1 million in funding for innovative prostate cancer research.
[Prostate Cancer Foundation] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Peter MacCallum Cancer Centre – Victoria, Australia |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Stanford University – Stanford, California, United States |
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