Prostate Cell News Volume 14.43 | Nov 10 2023

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    2023-11-10 | PCN 14.43


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.43 – 10 November, 2023
    TOP STORY

    PP2A Inhibition Causes Synthetic Lethality in BRCA2-Mutated Prostate Cancer Models via Reactivating Spindle Assembly Checkpoint

    Scientists conducted forward genetic synthetic viability screenings in C. elegans brc-2 (Cebrc-2) mutants and found that Ceubxn-2 inactivation rescued the viability of Cebrc-2 mutants.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract
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    MDA-9/Syntenin in the Tumor and Microenvironment Defines Prostate Cancer Bone Metastasis

    CXCL5-derived tumor cell proliferation and immune suppression were consequences of the melanoma differentiation associated gene-9 (MDA-9)/CXCL5 signaling axis, promoting prostate cancer disease progression.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    TGF-β Induces Matrisome Pathological Alterations and EMT in Patient-Derived Prostate Cancer Tumoroids

    Starting from patient cells, the authors established prostate cancer tumoroids and demonstrated that they required TGF-β signaling pathway activity to preserve phenotypical and structural similarities with the tissue of origin.
    [Matrix Biology]

    Abstract

    Androgen Receptor Inhibition Suppresses Anti-Tumor Neutrophil Response against Bone Metastatic Prostate Cancer via Regulation of TβRI Expression

    Using patient peripheral blood polymorphonuclear neutrophils, scientists identified that prostate cancer progression dictated polymorphonuclear neutrophils cell surface markers and gene expression, but not cytotoxicity against prostate cancer.
    [Cancer Letters]

    Full Article

    A Conserved Mechanism for JNK-Mediated Loss of Notch Function in Advanced Prostate Cancer

    Researchers demonstrated that increased activity of the Src-JNK pathway in tumors inactivated Notch signaling because of JNK pathway–mediated inhibition of the expression of the gene encoding the Notch S2 cleavage protease, Kuzbanian, which is critical for Notch activity.
    [Science Signaling]

    Abstract

    Integrated Machine Learning Identifies Epithelial Cell Marker Genes for Improving Outcomes and Immunotherapy in Prostate Cancer

    Employing consensus clustering analysis, scientists evaluated the correlations between epithelial cell marker genes, prognosis, and immune responses in prostate cancer.
    [Journal Of Translational Medicine]

    Full Article

    Implications of Albumin in Cell Culture Media on the Biological Action of Vanadates(V)

    The implications of binding competition of vanadates(V) with dodecyl sulfates for bovine serum albumin on cytotoxicity of vanadium(V) species against prostate cancer cells were investigated.
    [International Journal Of Biological Macromolecules]

    Full Article

    Semaphorin 3C Promotes De Novo Steroidogenesis in Prostate Cancer Cells

    Scientists showed that semaphorin 3C, a secreted signaling protein that is highly expressed in castration-resistant prostate cancer, could promote steroidogenesis by altering the expression profile of key steroidogenic enzymes.
    [Endocrine-Related Cancer]

    Full Article

    The Effect of Ganoderma lucidum Polysaccharide Extract on Sensitizing Prostate Cancer Cells to Flutamide and Docetaxel: An In Vitro Study

    The cytotoxic effects of Ganoderma lucidum polysaccharide in combination with docetaxel and flutamide on prostate cancer cells were investigated by the MTT test, Hoechst staining, and flow cytometry.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Versatile Design of Organic Polymeric Nanoparticles for Photodynamic Therapy of Prostate Cancer

    The authors provide an overview of the design, preparation, methodology, and oncological aspects of organic polymeric nanoparticles-based photodynamic therapy for the treatment of prostate cancer.
    [ACS Materials Au]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    House Lawmakers Launch Probe Into FDA’s Response to Nationwide Drug Shortages

    As shortages of drugs like amoxicillin, penicillin, Adderall and certain chemotherapies continue to confound doctors and patients in the US, two high-ranking Republican lawmakers are pressing the FDA for answers.
    [Fierce Pharma]

    Editorial
    FEATURED EVENT

    9th International Conference on Mechanics of Biomaterials and Tissues

    December 16 – 20, 2023
    Waikoloa Beach, Hawaii, United States

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    JOB OPPORTUNITIES

    Junior Group Leader – Cancer Research

    University of Cambridge – Cambridge, England, United Kingdom

    Assistant/Associate Professor – Prostate Cancer

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – Prostate Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Associate – Genetic Epidemiology

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

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