 | | Vol. 14.44 – 17 November, 2023 |
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| Germline inheritance of the adrenally permissive allele confers worse outcomes in men with advanced prostate cancer. Scientists investigated whether HSD3B1 (1245C) drove resistance to combined androgen deprivation and radiotherapy.
[Journal Of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Studies revealed that six-transmembrane epithelial antigen of prostate-2 (STEAP2) was a prevalent prostate cancer antigen that displayed high, homogeneous cell surface expression across all stages of disease with limited distal normal tissue expression.
[Journal Of Clinical Investigation] |
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| Researchers identified that deletion of DNA methyltransferases genes decreased expression of neuroendocrine lineage markers and substantially reduced neuroendocrine prostate cancer tumor development and metastasis in vivo.
[Science Translational Medicine] |
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| Using a series of co-culture, conditioned media, human cancer spheroid, and organ-on-a-chip experiments, the authors revealed that osteocytes suppressed cancer cell proliferation and increased migration via tumor necrosis factor alpha secretion.
[Advanced Science] |
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| Investigators demonstrated that CBX3 was abnormally upregulated in CDK4/6 inhibitors-resistant cells, and that CBX3 was almost positively correlated with the cell cycle in multiple malignancies and was downregulated by BET inhibitors.
[Advanced Science] |
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| Using in vitro functional assays, researchers demonstrated that NgR2 was crucial in promoting cell adhesion to αVβ3 ligands. They described for the first time co-fractionation of αVβ3 integrin and NgR2 in small extracellular vesicles derived from metastatic prostate cancer patients’ plasma.
[Matrix Biology] |
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| The authors explored the role of Ribonucleotide reductase subunit M2 (RRM2), a gene associated with senescence, in the sensitivity of prostate cancer to docetaxel.
[Cell & Bioscience] |
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| Expression of the ETS transcription factor ERG in prostate cells promoted PABPC1 localization to the nucleus and recruited PABPC1 to ERG/EWS binding sites in the genome.
[Journal Of Biological Chemistry] |
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| Functional analysis demonstrated that silencing of RFC2 expression inhibited cell proliferation and induced the expression of DNA damage and apoptosis markers in castration-resistant prostate cancer model cells.
[Scientific Reports] |
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| The authors take a comprehensive look at the clinical uses and synthetic methods of various significant small-molecule drugs that have been approved to treat prostate cancer.
[European Journal Of Medicinal Chemistry] |
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| “What we will do with this American Cancer Society grant is try to understand why sometimes senescence is good and stops tumors from growing and other times it’s bad and leads to immune suppression,” Dr. Ruscetti said.
[UMass Chan Medical School] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Stanford University – Stanford, California, United States |
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