Prostate Cell News Volume 14.45 | Nov 24 2023

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    Laurisa Dohm
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    2023-11-24 | PCN 14.45


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.45 – 24 November, 2023
    TOP STORY

    Temporal Evolution Reveals Bifurcated Lineages in Aggressive Neuroendocrine Small Cell Prostate Cancer Trans-Differentiation

    Scientists performed a multi-omics time course analysis of a pan-small cell neuroendocrine cancer model, a forward genetic transformation using human prostate basal cells and identified a shared developmental, arc-like, and entropy-high trajectory among all transformation model replicates.
    [Cancer Cell]

    Full ArticleGraphical Abstract
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    SND1 Binds to ERG and Promotes Tumor Growth in Genetic Mouse Models of Prostate Cancer

    Knocking down SND1 in human prostate epithelial cells, especially those overexpressing ERG, negatively impacted cell proliferation.
    [Nature Communications]

    Full Article

    The SMYD3-MAP3K2 Signaling Axis Promotes Tumor Aggressiveness and Metastasis in Prostate Cancer

    The authors demonstrated that SMYD3 critically regulated tumor-associated phenotypes via its methyltransferase activity in prostate cancer cells and mouse xenograft models.
    [Science Advances]

    Full Article

    Single-Cell RNA Sequencing of Human Prostate Basal Epithelial Cells Reveals Zone-Specific Cellular Populations and Gene Expression Signatures

    Using single-cell RNA sequencing of primary prostate epithelial cultures, scientists elucidated organ-specific, zone-specific, and cluster-specific gene expression differences in basal cells isolated from human prostate and seminal vesicle.
    [Journal Of Pathology]

    Full Article

    Spatial Transcriptomics Identifies Candidate Stromal Drivers of Benign Prostatic Hyperplasia

    Investigators demonstrated that insulin like growth factor 1 was necessary for the generation of benign prostatic hyperplasia-1 cell spheroids and patient-derived benign prostatic hyperplasia cell organoids in three-dimensional culture.
    [JCI Insight]

    AbstractFull ArticleGraphical Abstract

    MYC-Driven Increases in Mitochondrial DNA Copy Number Occur Early and Persist throughout Prostatic Cancer Progression

    The authors developed a multiplex in situ method to spatially quantify cell type specific mitochondrial DNA copy number, and showed that it was increased in luminal cells of high-grade prostatic intraepithelial neoplasia and in prostatic adenocarcinomas, and was further elevated in metastatic castration-resistant prostate cancer.
    [JCI Insight]

    AbstractFull Article

    Targeting DGAT1 Inhibits Prostate Cancer Cells Growth by Inducing Autophagy Flux Blockage via Oxidative Stress

    Researchers investigated the role of diacylglycerol acyltransferases 1 (DGAT1) and its potential effects on cellular energy homeostasis and autophagy flux in prostate cancer.
    [Oncogene]

    AbstractGraphical Abstract

    Photothermal Performance of a Novel Carbon Dot and Its Conjugate with Disulfiram for Prostate Cancer PC3 Cell Therapy

    Copper, sulfur, nitrogen–carbon quantum dot nanoparticles loaded with the chemotherapy drug disulfiram were tested on the prostate cancer cell line PC3.
    [Nanomedicine]

    Abstract

    Adaptor Proteins Mediate CXCR4 and PI4KA Crosstalk in Prostate Cancer Cells and the Significance of PI4KA in Bone Tumor Growth

    Investigators identified that chemokine receptor CXCR4 bound to PI4KIIIα adaptor proteins TTC7 and this interaction induced plasma membrane PI4P production in prostate cancer cells.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Emerging Frontiers in Nanomedicine Targeted Therapy for Prostate Cancer

    The authors highlight therapeutic nanoparticles as a solution for prostate cancer chemotherapy, exploring targeting strategies and approaches to combat drug resistance.
    [Cancer Treatment and Research Communications]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Prostate Cancer Research to Receive $5 Million with New CAR T Cell Therapy

    Professor Gail Risbridger and her research team from Monash University will receive $5 million in funding over 5 years for research to advance immunotherapy treatments for treating prostate cancer.
    [NHMRC]

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