 | | Vol. 14.46 – 1 December, 2023 |
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| Researchers detected that the replacement of androgen receptor by glucocorticoid receptor in enzalutamide-exposed prostate cancer cells occured almost exclusively at pre-accessible chromatin sites displaying FOXA1 occupancy.
[Nucleic Acids Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that the RNA-binding protein ELAVL3 was specifically upregulated in neuroendocrine prostate cancer and that overexpression of ELAVL3 alone was sufficient to induce the neuroendocrine phenotype in prostate adenocarcinoma.
[Nature Communications] |
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| Investigators demonstrated that tumor-associated macrophages-secreted taurine suppressed ferroptosis in prostate cancer by activating the Liver X receptor alpha/Stearoyl-Coenzyme A desaturase 1 pathway.
[Advanced Science] |
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| Scientists observed changes which affected proliferation, colony formation, and 3D-spheroid growth of multiple epithelial prostate cancer cell models.
[Oncogene] |
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| CCK8 assays, EdU assays, Scratch assay and Transwell migration assay were conducted to detect the role of circTENM3 in prostate cancer cells in vitro.
[Journal of Translational Medicine] |
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| The compound discovered exhibited high selectivity among 215 kinases and significantly suppressed the proliferation and metastasis of prostate cancer cells in vitro.
[Journal Of Medicinal Chemistry] |
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| Researchers explored the function of regulator of chromosome condensation 2 (RCC2) on prostate cancer (PCa) development. They found that RCC2 promoted PCa development through Hh/Gli1 signaling pathway via regulating epithelial-mesenchymal transition and cancer stem-like cells.
[Biology Direct] |
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| Scientists monitored cell viability in organoids, tumor volume, and PSA secretion in patient-derived xenografts and analyzed cell cycle and signaling pathway alterations.
[Molecular Cancer Therapeutics] |
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| The authors investigated the effect of carnosine on cell proliferation and metabolism in both a primary cultured androgen-resistant human prostate cancer cell line, and murine cells.
[Journal Of Cellular And Molecular Medicine] |
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| In a number of cancers, including carcinoma of the mammary gland, endometrium, liver, prostate, and colon, the expression of growth hormone is independently associated with more advanced clinicopathologic parameters of the cancer.
[Endocrine-Related Cancer] |
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| The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.
[Nature News] |
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| January 25 – 27, 2024
Vienna, Austria |
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| | Institut Necker Enfants Malades – Paris, France |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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