 | | Vol. 14.47 – 8 December, 2023 |
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| Scientists developed an approach to perform metabolomics on primary prostate epithelial cells, and using this approach, discovered that the basal and luminal cells of the prostate exhibited distinct metabolomes and nutrient utilization patterns.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors introduced Promoter-Enhancer-Guided Interaction Networks (PENGUIN), a method for studying protein-protein interaction networks within enhancer-promoter interactions. PENGUIN was validated using cancer and benign prostate cell lines.
[Nature Communications] |
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| The correlation between YAP1 expression and fibrosis in human and rat benign prostatic hyperplasia specimens was analyzed, and the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, were also studied.
[Advanced Science] |
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| Molecular, genetic, or pharmacological inhibition of adipose triglyceride lipase impaired human and murine prostate cancer growth in vivo and in cell culture or organoids under conditions mimicking the tumor microenvironment.
[Cancer Research] |
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| Researchers examined the function and effects of circKIF18B_003 in prostate cancer cells using CCK-8, colony formation, wound healing, and Transwell invasion assays and xenograft models.
[Journal Of Translational Medicine] |
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| In vitro experiments demonstrated that silencing HOXC13 inhibited 22RV1 and DU145 cell function by inducing cellular DNA damage and activating cGAS/STING/IRF3 pathway.
[Journal Of Translational Medicine] |
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| In vitro experiments on prostate cancer cells showed that TE6 inhibited PLK1 protein expression, and consequently cell proliferation, by blocking the cell cycle at G2 phase.
[Biochemical Pharmacology] |
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| The mechanism of action of miR-361-3p was investigated using western blotting, luciferase reporter assays, immunofluorescence, and rescue studies.
[Cellular Signalling] |
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| Loss-of-function assays demonstrated that silencing of PDZ and LIM Domain 7 (PDLIM7) could suppress CRPC cell proliferation, migration, and angiogenesis.
[Translational Oncology] |
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| The authors summarize the recent studies which mainly focused on the role of tumor microenvironment or bone microenvironment in the CRPC patients with bone metastasis, and discussed the underlying mechanisms.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| The “proposed framework” would clarify that a tool for removing patent protection to ensure a government-funded invention is commercialized can be used for an overly pricey drug so that other companies can sell it more cheaply.
[Science Insider] |
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| February 22 – 24, 2024
Austin, Texas, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Institut Necker Enfants Malades – Paris, France |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Southern California – Los Angeles, California, United States |
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