Prostate Cell News Volume 14.48 | Dec 15 2023

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    2023-12-14 | PCN 14.48


    Prostate Cell News by STEMCELL Technologies
    Vol. 14.48 – 15 December, 2023
    TOP STORY

    ADP-Dependent Glucokinase Controls Metabolic Fitness in Prostate Cancer Progression

    The effect of ADP-dependent glucokinase expression on prostate cancer cell malignant phenotypes was validated in vitro and in vivo.
    [Military Medical Research]

    Full Article
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    Interleukin-30 Subverts Prostate Cancer-Endothelium Crosstalk by Fostering Angiogenesis and Activating Immunoregulatory and Oncogenic Signaling Pathways

    Prostate cancer-endothelial cell interactions were investigated, after coculture, by flow cytometry, transcriptional profiling, western blot, and ELISA assays.
    [Journal Of Experimental & Clinical Cancer Research]

    Abstract

    Secreted miR-210-3p, miR-183-5p and miR-96-5p Reduce Sensitivity to Docetaxel in Prostate Cancer Cells

    The authors showed that miR-96-5p, miR-183-5p and miR-210-3p were specifically released by docetaxel resistant prostate cancer clones, and decreased the efficacy of docetaxel in prostate cancer cells when overexpressed.
    [Cell Death Discovery]

    Full Article

    Inhibition of Orthotopic Castration-Resistant Prostate Cancer Growth and Metastasis in Mice by JC VLPs Carrying a Suicide Gene Driven by the PSA Promoter

    Investigators established an iRFP stable expression CRPC cell line suitable for deep-tissue observation using fluorescence molecular tomography, and these cells were implanted into murine prostate tissue.
    [Cancer Gene Therapy]

    Full Article

    The Effects of Glycemic Index on Prostate Cancer Progression in a Xenograft Mouse Model

    Scientists tested whether modifying carbohydrate quality to lower glycemic index, without changing quantity, resulted in similar benefits as with reduced quantityl, in the context of prostate cancer growth.
    [Prostate Cancer And Prostatic Diseases]

    Full Article

    A Low or High Physical Activity Level Does Not Modulate Prostate Tumor Tissue Protein Synthesis Rates

    Daily deuterium oxide administration was combined with the collection of plasma, skeletal muscle, non-tumorous prostate, and prostate tumor tissue during the surgical procedure to determine tissue protein synthesis rates throughout the intervention period.
    [Medical Science in Sports & Exercise]

    Abstract

    Association of WHSC1/NSD2 and T Cell Infiltration with Prostate Cancer Metastasis and Prognosis

    Investigators found that the positive expression rate of NSD2 increased progressively in benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and prostate cancer.
    [Scientific Reports]

    Full Article

    Targeting Glutamine Dependence with DRP-104 Inhibits Proliferation and Tumor Growth of Castration-Resistant Prostate Cancer

    Human prosate cancer cell lines were treated with the prodrug DRP-104 and effects on proliferation and cell death were assessed.
    [Prostate]

    Abstract

    4-Octyl Itaconate Alleviates Experimental Autoimmune Prostatitis by Inhibiting the NLRP3 Inflammasome-Induced Pyroptosis through Activating Nrf2/HO-1 Pathway

    The animal experiment component induced experimental autoimmune prostatitis in non-obese diabetic mice through intradermal prostate antigen injection and complete Freund’s adjuvant.
    [Prostate]

    Abstract
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    REVIEWS

    Biomarkers and Targeted Therapy for Cancer Stem Cells

    Scientists provide an overview of the unique signaling and metabolic pathways of CSCs, summarize existing CSC biomarkers and CSC-targeted therapies, and discuss strategies to further differentiate CSCs from non-stem cancer cells.
    [Trends In Pharmacological Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cancer Council Victoria Funding for Mesothelioma and Prostate Cancer Research

    Two Monash Biomedicine Discovery Institute early career researchers have been awarded two of Cancer Council Victoria’s four annually awarded Postdoctoral Research Fellowships, Dr. Porter’s project seeks to harness the power of the immune system to fight prostate cancer through CAR T cell therapy.
    [Monash University]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Global Clinical Lead – Prostate Cancer

    Pfizer – Multiple Locations, United States

    Postdoctoral Position – Cancer Biology

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Scientists – Regulatory Lymphocytes & Tissue Resident Cells Crosstalk

    Institut Necker Enfants Malades – Paris, France

    Postdoctoral Fellow – Prostate Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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