 | | Vol. 15.02 – 19 January, 2024 |
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| HOXB13 is an androgen receptor co-regulator specifically expressed in cells of prostatic lineage. The authors sought to associate circulating tumor cell HOXB13 expression with outcomes in men with metastatic castration-resistant prostate cancer treated with abiraterone or enzalutamide.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Whole proteome analysis connected low androgen receptor to interleukin-specific gene expression, while compromised genome stability and tumorigenesis were also supported by interferons.
[Cell Death & Disease] |
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| By exploiting the recognition properties of lactoferrin receptors that target intestinal epithelial cells and prostate epithelial cells, a pathway was established for the transrectal absorption of Emodin to effectively reach the prostate.
[Journal Of Nanobiotechnology] |
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| Antigen presentation and process-related cancer-associated fibroblasts (APPCAFs ) were identified using bioinformatics, and the clinical implications of APPCAF-related signatures in PRAD were investigated.
[Journal Of Translational Medicine] |
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| The compound identified exhibited much superior activity in inhibiting the proliferation and colony formation and inducing apoptosis of the castration-resistant prostate cancers cell lines relative to a positive control and noncovalent control.
[Journal Of Medicinal Chemistry] |
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| Scientists compared the impact of PI3K/AKT/mTOR pathway inhibitors with different selectivity profiles on in vitro cell proliferation and on caspase 3/7 activation as a marker for apoptosis induction, and observed the strongest effects in the androgen-sensitive prostate cancer cell lines VCaP and LNCaP.
[Molecular Oncology] |
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| Dihydropyrimidinase-related protein 5 (DPYSL5) overexpression in prostate cancer cells induced a neuron-like phenotype, enhanced invasion, proliferation, and upregulated stemness and neuroendocrine-related markers.
[Communications Biology] |
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| The role of SIRT1/GLUT1 signaling was investigated in the apoptotic effect of Leptosidin from Coreopsis grandiflora in DU145 and PC3 human prostate cancer cells.
[Phytotherapy Research] |
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| The effects of Bisphenol A on the prostate were investigated in this study using mouse and human prostate cell models.
[Food And Chemical Toxicology] |
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| The authors outline and discuss recent progress in our understanding of the role of exosomes in the prostate cancer microenvironment, like their involvement in prostate cancer occurrence, progression, angiogenesis, epithelial–mesenchymal transition, metastasis, and drug resistance.
[Biofactors] |
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| Poor-quality studies are polluting the literature — a group will study the businesses that produce them to stem the flow of bogus research.
[Nature News] |
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| March 24 – 29, 2024
Galveston, Texas, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | The Vancouver Prostate Centre – Vancouver, British Columbia, Canada |
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| | Human Technopole – Milan, Italy |
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| | Jefferson-Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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