Prostate Cell News Volume 15.05 | Feb 09 2024

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    2024-02-09 | PCN 15.05


    Prostate Cell News by STEMCELL Technologies
    Vol. 15.05 – 9 February, 2024
    TOP STORY

    Boosting Sono-Immunotherapy of Prostate Carcinoma through Amplifying Domino-Effect of Mitochondrial Oxidative Stress Using Biodegradable Cascade-Targeting Nanocomposites

    Investigators prepared MCTH nanocomposites consisting of disulfide bonds doped mesoporous organosilica, Cu-modified protoporphyrin, mitochondria-targeting triphenylphosphine, and CD44-targeting hyaluronic acid.
    [ACS Nano]

    AbstractGraphical Abstract
    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Sterile Inflammation via TRPM8 RNA-Dependent TLR3-NF-kB/IRF3 Activation Promotes Antitumor Immunity in Prostate Cancer

    Prostate cells secreted TRPM8 RNA into extracellular vesicles, which primed TLR3/NF-kB-mediated inflammatory signaling after extracellular vesicle endocytosis by epithelial cancer cells.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    ERBB3 Overexpression Is Enriched in Diverse Patient Populations with Castration-Sensitive Prostate Cancer and Is Associated with a Unique AR Activity Signature

    Neutralizing antibody patritumab and ectopic HER3 overexpression were utilized for functional mechanistic experiments.
    [Clinical Cancer Research]

    Abstract

    Co-Axial Hydrogel Spinning for Facile Biofabrication of Prostate Cancer-Like 3D Models

    A spatial cellular position and 3D architecture, containing dual compartments with different hydrogel materials, was engineered using a simple co-axial nozzle setup, in a single step utilizing prostate as a model of glandular cancer.
    [Biofabrication]

    Abstract

    1-Pyrroline-5-Carboxylate Inhibits T Cell Glycolysis in Prostate Cancer Microenvironment by SHP1/PKM2/LDHB Axis

    Investigators produced an antibody for targeting 1-Pyrroline-5-Carboxylate (P5C) by monoclonal technique and verified that the antibody could oppose the influence of P5C The antibody also inhibited the growth of prostate tumors in an animal model.
    [Cell Communication And Signaling]

    Full Article

    Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Ameliorate Male Infertility Caused by Busulfan In Vivo and In Vitro

    Scientists explored the functional restoration and mechanism of Human umbilical cord MSC exosomes on busulfan-induced injury in GC-1 spg cells and ICR mouse testes.
    [Ecotoxicology And Environmental Safety]

    Full Article

    Exploring the Mechanism of Action of Sparganii Rhizoma-Curcumae Rhizoma for in Treating Castration-Resistant Prostate Cancer: A Network-Based Pharmacology and Experimental Validation Study

    The active ingredients and core targets were verified through molecular docking and were validated using PC3 cells in the experimental validation phase.
    [Scientific Reports]

    Full Article

    A Novel Exosome Based Therapeutic Intervention against Neuroendocrine Prostate Cancer

    In vitro experiments with neuroendocrine prostate cancer (NEPC) cell lines demonstrated that CEACAM5-targeted exosomes were specifically taken up by NEPC cells, leading to reduced cellular viability and decreased expression of neuronal markers.
    [Scientific Reports]

    Full Article

    Anti-Cancer Activity of Zinc-Tetraphenylporphyrin Photosensitizer/Dextran-Graft-Polyacrylamide Copolymer/Au(Ag) Nanoparticle Nanohybrids

    A comparative study of in vitro anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran-graft-polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids on LNCaP prostate cancer cells was carried out.
    [Rsc Advances]

    Abstract
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    REVIEWS

    The Yin and Yang of Chromosomal Instability in Prostate Cancer

    In the context of prostate cancer, studies indicate that chromosomal instability has a key role in disease progression and might also offer a therapeutic vulnerability that can be pharmacologically targeted.
    [Nature Reviews Urology]

    Abstract
    INDUSTRY AND POLICY NEWS

    US and China Likely to Delay Renewal of Key Science Pact Again

    China and the United States will once again probably delay the renewal of a decades-old pact to cooperate on science and technology. The two nations have been negotiating for the past six months, but need more time to settle new terms and conditions requested by both sides, sources tell Nature.
    [Nature News]

    Full Article
    FEATURED EVENT

    2024 Cincinnati International Symposium

    April 4 – 5, 2024
    Cincinnati, Ohio, United States

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    JOB OPPORTUNITIES

    Senior Research Assistant – Epigenetics & Molecular Carcinogenesis

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Senior Medical Director – Prostate Cancer

    Pfizer – Multiple Locations, United States

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    Laboratory Research Assistant – Benign Prostate Hyperplasia

    The Vancouver Prostate Centre – Vancouver, British Columbia, Canada

    Postdoctoral Research Fellow – Prostate Cancer

    Jefferson-Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    > See All Jobs

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