| Vol. 15.05 – 9 February, 2024 |
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| Investigators prepared MCTH nanocomposites consisting of disulfide bonds doped mesoporous organosilica, Cu-modified protoporphyrin, mitochondria-targeting triphenylphosphine, and CD44-targeting hyaluronic acid. [ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Prostate cells secreted TRPM8 RNA into extracellular vesicles, which primed TLR3/NF-kB-mediated inflammatory signaling after extracellular vesicle endocytosis by epithelial cancer cells. [EMBO Journal] |
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| Neutralizing antibody patritumab and ectopic HER3 overexpression were utilized for functional mechanistic experiments. [Clinical Cancer Research] |
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| A spatial cellular position and 3D architecture, containing dual compartments with different hydrogel materials, was engineered using a simple co-axial nozzle setup, in a single step utilizing prostate as a model of glandular cancer. [Biofabrication] |
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| Investigators produced an antibody for targeting 1-Pyrroline-5-Carboxylate (P5C) by monoclonal technique and verified that the antibody could oppose the influence of P5C The antibody also inhibited the growth of prostate tumors in an animal model. [Cell Communication And Signaling] |
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| Scientists explored the functional restoration and mechanism of Human umbilical cord MSC exosomes on busulfan-induced injury in GC-1 spg cells and ICR mouse testes. [Ecotoxicology And Environmental Safety] |
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| The active ingredients and core targets were verified through molecular docking and were validated using PC3 cells in the experimental validation phase. [Scientific Reports] |
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| In vitro experiments with neuroendocrine prostate cancer (NEPC) cell lines demonstrated that CEACAM5-targeted exosomes were specifically taken up by NEPC cells, leading to reduced cellular viability and decreased expression of neuronal markers. [Scientific Reports] |
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| A comparative study of in vitro anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran-graft-polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids on LNCaP prostate cancer cells was carried out. [Rsc Advances] |
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| In the context of prostate cancer, studies indicate that chromosomal instability has a key role in disease progression and might also offer a therapeutic vulnerability that can be pharmacologically targeted. [Nature Reviews Urology] |
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| China and the United States will once again probably delay the renewal of a decades-old pact to cooperate on science and technology. The two nations have been negotiating for the past six months, but need more time to settle new terms and conditions requested by both sides, sources tell Nature. [Nature News] |
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| April 4 – 5, 2024 Cincinnati, Ohio, United States |
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| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Pfizer – Multiple Locations, United States |
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| University of Birmingham – Birmingham, England, United Kingdom |
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| The Vancouver Prostate Centre – Vancouver, British Columbia, Canada |
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| Jefferson-Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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