 | | Vol. 15.07 – 23 February, 2024 |
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| Investigators found heterogeneous expression of the prolactin receptor (PRLR) in clinical prostate samples. The VCaP and 22Rv1 cells exhibited PRLR expression. Among the downstream proteins, STAT5B was the dominant subtype in clinical samples and cell lines.
[Cell Death & Disease] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the expression of heat shock protein family B (HSPB6) in prostate cancer and its association with prognosis. Their findings revealed that HSPB6 downregulation in prostate cancer correlated with a poor prognosis.
[Cell Death Discovery] |
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| Scientists investigated the design and synthesis of the first estrogen receptor (ERβ) and histone deacetylases dual-target near-infrared fluorescent probe with both imaging capacity and antitumor activity for prostate cancer.
[European Journal Of Medicinal Chemistry] |
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| Researchers investigated the anti-prostate cancer effect of a drug candidate named GL-V9 and highlight the significant mechanism involving the AKT-HKII pathway.
[iScience] |
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| Novel coumarin derivatives were synthesized and tested for their cytotoxicity against human cancer cells. Compounds 5, 4b, and 4a possessed potent cytotoxic activity against PC-3 cells with IC50 3.56, 8.99, and 10.22 µM, respectively.
[Journal Of Enzyme Inhibition And Medicinal Chemistry] |
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| The human prostate stromal cell line (WPMY-1), rat prostate epithelial cells, human prostate tissues and two BPH rat models were employed in this study.
[International Journal Of Biochemistry & Cell Biology] |
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| Researchers attempted to develop sufficient phytochemical information on two understudied species, Staudtia kamerunensis Warb. (Myristicaceae) and Hypodaphnis zenkeri Engl. Stapf. (Lauraceae), and studied their cytotoxicity against prostate cancer cells in its early form and when they have developed metastasis.
[Journal Of Ethnopharmacology] |
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| Investigators explored the molecular mechanism behind the role of α-LA as therapeutics in preventing prostate cancer (PCa) and its associated bone modulation. Notably, α-LA treatment significantly reduced the cell viability, migration, and invasion of PCa cell lines in a dose-dependent manner.
[Scientific Reports] |
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| Cell proliferation was examined in CRPC PC-3 and DU-145 cells using sulforhodamine B assay and anchorage-dependent colony formation assay. Flow cytometric analysis of propidium iodide staining was used to determine cell-cycle progression.
[Prostate] |
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| De novo post-translational acetylation of the AR, HOXB13, and H2A at K609, K13, and K130, respectively, and phosphorylation of H4 at Y88 have emerged as key epigenetic modifications associated with CPRC.
[Trends In Cancer] |
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| The dysregulation in molecular profile of prostate cancer including upregulation of STAT3 and PI3K/Akt, downregulation of STAT3, and aberrant expression of non-coding RNAs are determining factor for response of cancer cells to chemotherapy.
[Cancer And Metastasis Reviews] |
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| Scientists focus on multifaceted resistance mechanisms, including androgen receptor overexpression, splice variants, missense mutations, and alterations in coregulators and transcription factors, revealing their roles in castration-resistant prostate cancer progression.
[International Journal Of Urology] |
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| Celcuity, Inc. announced that the first patient has been dosed in its Phase Ib/II study evaluating gedatolisib in combination with Nubeqa®, an approved androgen receptor inhibitor, for the treatment of patients with metastatic CPRC.
[Celcuity, Inc. (GlobeNewswire, Inc.)] |
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| Dr. Syam Somasekharan has been honored with the Idea Development Award – Established Investigator Award in Urologic Sciences by the US Department of Defense Congressionally Directed Medical Research Programs for his exceptional work in identifying biomarkers and therapeutic targets for prostate cancer.
[Vancouver Prostate Centre] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | The Henry M. Jackson Foundation – Bethesda, Maryland, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Augusta University – Augusta, Georgia, United States |
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