 | | Vol. 15.11 – 19 April, 2024 |
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| Researchers found that combining a fatty acid synthase (FASN)i with the poly-ADP ribose polymerase (PARP) inhibitor olaparib, which induced cell death by blocking DNA damage repair, resulted in a more pronounced reduction in cell growth than that caused by either drug alone.
[Science Signaling] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described a novel micro-surgical technique for orthotopically implanting intact tumors pieces from cell line derived or patient derived tumors in the mouse prostate gland and monitored tumor growth using magnetic resonance imaging.
[The Prostate] |
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| Investigators established a technique for intraprostatic implantation of prostate cancer (PCa) spheroids and to identify the impact of three-dimensional organization of PCa cells on tumor progression and metastasis in a representative in vivo model.
[Scientific Reports] |
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| Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.
[Cell Death & Disease] |
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| The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.
[iScience] |
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| Nucleolar proteomics data and large-scale immunofluorescence were re-analyzed to jointly identify the proteins localized at nucleolus. RNA-Seq data of five prostate cancer (PCa) cohorts were combined and integrated with multi-dimensional data to define the upregulated nucleolar transcription factors in PCa tissues.
[The Prostate] |
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| The authors describe novel molecular underpinnings and metabolic drivers of ferroptosis, analyze the functions and mechanisms of ferroptosis in tumors, and highlight prostate cancer-specific susceptibilities to ferroptosis.
[Nature Reviews Urology] |
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| Investigators explore PARP nuclear functions, inhibition, and clinical relevance through the lens of racial differences.
[Cancer Research] |
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| The Research Institute of McGill University Health Centre has enrolled the first patients to take part in an early-stage, multi-centre clinical trial of Actinium-225, a radioactive isotope used as a treatment for metastatic prostate cancer.
[McGill University Health Centre] |
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| Dr Kevin Koo, from The University of Queensland’s (UQ) Centre for Clinical Research, has been awarded one of five new research grants worth a combined value of $1.2 million from the Prostate Cancer Foundation of Australia.
[The University of Queensland] |
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| | University of Sydney – Sydney, Australia |
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| | Fondazione per l’Istituto oncologico di ricerca – Bellinzona, Switzerland |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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