LABORATORY RESEARCH Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers A new technology was demonstrated to enrich circulating tumor cells with high efficiency by integrating an antibody-coated silicon nanopillar substrate with an overlaid polydimethylsiloxane microfluidic chaotic mixer. [Angew Chem Int Ed Engl] PrLZ Protects Prostate Cancer Cells from Apoptosis Induced by Androgen Deprivation via the Activation of Stat3/Bcl-2 Pathway In this study, scientists showed that PrLZ enhanced in vitro growth and colony formation of prostate cancer cells on androgen deprivation as well as tumorigenicity in castrated nude mice. [Cancer Res] Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression The goal of this study was to investigate alterations in androgen receptor (AR) expression arising in a cell-based model of prostate cancer progression driven by truncated AR isoform activity. [Cancer Res] Large Scale Exploration of Gene-Gene Interactions in Prostate Cancer Using a Multi-Stage Genome-Wide Association Study Researchers explored evidence of interaction between pairs of 13 known susceptibility loci and single nucleotide polymorphisms across the genome to generate hypotheses about the functionality of prostate cancer susceptibility regions. [Cancer Res] Regulation of HMGA1 Expression by MicroRNA-296 Affects Prostate Cancer Growth and Invasion In this study, investigators examined the functional relation between microRNA-296 and high-motility group AT-hook gene 1 (HMGA1) expression in several prostate cancer (PC) cell lines and a large PC cohort. [Clin Cancer Res] Oct1 Regulates Cell Growth of LNCaP Cells and Is a Prognostic Factor for Prostate Cancer In the present study, the contribution of octamer transcription factor 1 (Oct1) to prostate cancer development was examined. [Int J Cancer] Absence of Scavenger Receptor A Promotes Dendritic Cell-Mediated Cross-Presentation of Cell-Associated Antigen and Antitumor Immune Response Using OVA-expressing RM1 prostate tumor line, scientists show for the first time that scavenger receptor A absence greatly enhances dendritic cells-mediated cross-presentation of OVA antigen derived from dying RM1 cells. [Immunol Cell Biol] CLINICAL RESEARCH The Association Between Diffusion of the Surgical Robot and Radical Prostatectomy Rates The objective of the study was to determine the relationship between surgical robot acquisition and changes in volume of radical prostatectomy at the regional and hospital levels. [Med Care] α1-Adrenoceptor Activation Induces Phosphorylation of β2-Adrenoceptors in Human Prostate Tissue The objective of the study was to test whether β1-adrenoceptor activation leads to phosphorylation of the β2-adrenoceptor in human prostate tissue. [BJU Int] Visceral Obesity and Inflammation Markers in Relation to Serum Prostate Volume Biomarkers Among Apparently Healthy Men The associations of adiponectin and waist–hip ratio strengthen the link between insulin resistance and visceral adiposity to prostate volume markers among apparently healthy Arab men. [Eur J Clin Invest] |