LABORATORY RESEARCH
Hallmarks of Cancer: The Next Generation The hallmarks of cancer constitute an organizing principle for rationalizing the complexities of neoplastic disease. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list – reprogramming of energy metabolism and evading immune destruction. [Cell]
Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma Here scientists present the first in vivo genetic evidence that protein kinase C epsilon (PKCe) is essential for both the development and metastasis of prostate cancer in the transgenic mouse model of prostate adenocarcinoma (TRAMP). [Cancer Res]
Garlic Constituent Diallyl Trisulfide Suppresses X-Linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture and In Vivo The present study systematically investigates role of inhibitor of apoptosis family proteins in regulation of diallyl trisulfide (DATS)-induced apoptosis using cultured PC-3 and LNCaP human prostate cancer cells and dorsolateral prostate from control and DATS-treated Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. [Cancer Prev Res] Transgenic Expression of Polyoma Virus Middle T Antigen in the Mouse Prostate Gives Rise to Carcinoma In this study, investigators generated transgenic mice in which middle T is expressed in the mouse prostate under the control of an (ARR)2-Probasin promoter. [J Virol] The Metastasis Suppressor, N-MYC Downstream Regulated Gene 1 (NDRG1), UP-Regulates P21 Via P53-Independent Mechanisms The current study was focused on further elucidating the molecular mechanisms behind the anti-tumor function of NDGR1. [Carcinogenesis] MiRNA Profiles of Prostate Carcinoma Detected by Multi-Platform miRNA Screening To characterize the diagnostic potential of microRNAs (miRNAs) in prostate cancer, scientists performed screening of miRNA expression profiles. [Int J Cancer] ?-Tocotrienol Induces Apoptosis and Autophagy in Prostate Cancer Cells by Increasing Intracellular Dihydrosphingosine and Dihydroceramide Here researchers showed that ?-tocotrienol treatment promoted apoptosis, necrosis and autophagy in human prostate PC-3 and LNCaP cancer cells. [Int J Cancer] High-Level Expression of Forkhead-Box Protein A1 in Metastatic Prostate Cancer The aim of this study was to investigate the expression and potential role of forkhead-box protein A1 and GATA3 transcription factors as prognostic factors in prostate cancer. [Histopathology] CLINICAL RESEARCH
Cost Implications of the Rapid Adoption of Newer Technologies for Treating Prostate Cancer Using Surveillance, Epidemiology, and End Results–Medicare linked data, investigators determined treatment patterns for 45,636 men age 65 years or older who received definitive surgery or radiation for localized prostate cancer diagnosed from 2002 to 2005. [J Clin Oncol]
Serum Retinol and Risk of Prostate Cancer The authors prospectively examined prostate cancer risk and serum retinol levels, measured by using high-performance liquid chromatography, at baseline (n = 29,104) and after 3 years (n = 22,843) in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. [Am J Epidemiol]
Impact of Androgen Deprivation on Physical Well-Being in Patients with Prostate Cancer: Analysis from the CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) Registry In this study, the authors evaluated the effect of androgen deprivation therapy administered as monotherapy and in combination with local treatment on physical well-being in a longitudinal sample of men with prostate cancer. [Cancer]
Cysteine-Rich Secretory Protein 3 and ß-Microseminoprotein on Prostate Cancer Needle Biopsies Do Not Have Predictive Value for Subsequent Prostatectomy Outcome To investigate whether cysteine-rich secretory protein 3 and/or ß-microseminoprotein expression in diagnostic prostate needle biopsies have predictive value for prostate cancer on radical prostatecomy. [BJU Int] |