Prostate Cell News Volume 2.14 | Apr 15 2011

Insulin-Like Growth Factor-Binding Protein-2 Promotes Prostate Cancer Cell Growth Via Insulin-Like Growth Factor-Dependent or -Independent Mechanisms and Reduces the Efficacy of Docetaxel
The aim of this study is to investigate the effects of insulin-like growth factor-binding protein-2 on prostate cancer cell proliferation and its effects on the response to docetaxel. [Br J Cancer]

Bone Marrow-Derived Macrophages Are Associated with Androgen Modulated Prostate Regeneration
The observation that bone marrow-derived macrophages are recruited into the prostate where they associate with prostate regeneration suggests that bone marrow-derived macrophages are involved in prostate regeneration. [Prostate]

Chemotherapy Sensitivity Recovery of Prostate Cancer Cells by Functional Inhibition and Knock Down of Multidrug Resistance Proteins
Using primary cell cultures from prostate cancer patients, researchers evaluated the effect of function and expression inhibition of p-glycoprotein, MRP1, and LRP, on cell survival after chemotherapy exposure. [Prostate]

Combined Treatment Targeting HIF-1α and Stat3 Is a Potent Strategy for Prostate Cancer Therapy
To develop a potent strategy to increase therapeutic efficacy and reduce drug resistance in prostate cancer therapy, investigators combined two anti-cancer agents: T40214 (a p-Stat3 inhibitor) and JG244 (a hypoxia-inducible factor-1α (HIF-1α) inhibitor) together to treat nude mice bearing human prostate tumor (DU145) and immunocompetent mice (C57BL/6) bearing murine prostate tumor (TRAMP-C2). [Prostate]

CLINICAL RESEARCH

Active Surveillance Program for Prostate Cancer: An Update of the Johns Hopkins Experience
The purpose of this study is to assess the outcomes of men with prostate cancer enrolled in active surveillance. [J Clin Oncol]

Randomized, Open-Label Phase III Trial of Docetaxel Plus High-Dose Calcitriol Versus Docetaxel Plus Prednisone for Patients with Castration-Resistant Prostate Cancer
The purpose of this study is to compare the efficacy and safety of docetaxel plus high-dose calcitriol (DN-101) to docetaxel plus prednisone in an open-label Phase III trial. [J Clin Oncol]

Phase I Dose-Escalation Study of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer
The purpose of this study is to evaluate the tolerability of escalating doses of stereotactic body radiation therapy in the treatment of localized prostate cancer. [J Clin Oncol]

Prostate-Specific Antigen (PSA) Isoform p2PSA Significantly Improves the Prediction of Prostate Cancer at Initial Extended Prostate Biopsies in Patients with Total PSA Between 2.0 and 10 ng/ml: Results of a Prospective Study in a Clinical Setting
The objective of this study is to compare the diagnostic accuracy of PSA isoform p2PSA and its derivatives in determining the presence of prostate cancer at initial biopsy with the accuracy of other predictors in patients with total PSA 2.0-10 ng/ml. [Eur Urol]

The Sensitivity of [¹¹C]Choline PET/CT to Localize Prostate Cancer Depends on the Tumor Configuration
The purpose of this study is to evaluate the dependency of the sensitivity of [¹¹C]choline-PET/CT for detecting and localizing primary prostate cancer on tumor configuration in the histologic specimen. [Clin Cancer Res]

Decision Tree-Based Modeling of Androgen Pathway Genes and Prostate Cancer Risk
The objective of this analysis is to evaluate interactions for prostate cancer risk using classification and regression trees and to evaluate whether these interactive effects add information about risk prediction beyond that of “traditional” risk factors. [Cancer Epidemiol Biomarkers Prev]