LABORATORY RESEARCH Effect of ON 01910.Na, an Anticancer Mitotic Inhibitor, on Cell Cycle Progression Correlates with RanGAP1 Hyperphosphorylation Scientists examined ON 01910.Na (benzyl styryl sulfone)’s effect on DNA damage signaling molecules upstream of Cdc25C, (Chk1, Chk2, and H2AX), as well as on RanGAP1·SUMO1, a mitosis coordinator. [Cancer Res] The Suppression of Prostate LNCaP Cancer Cells Growth by Selenium Nanoparticles through Akt/Mdm2/AR Controlled Apoptosis Researchers prepared selenium nanoparticles and investigated its inherent anticancer mechanisms. They found that selenium nanoparticles inhibit growth of prostate LNCaP cancer cells partially through caspases mediated apoptosis. [Biomaterials] Phosphorylation and Interaction of Myopodin by Integrin-Link Kinase Lead to Suppression of Cell Growth and Motility in Prostate Cancer Cells In this report, investigators showed that the N-terminus of myopodin binds integrin-linked kinase both in vitro and in vivo. [Oncogene] Image-Guided Prostate Cancer Therapy Using Aptamer-Functionalized Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles After Dox molecules were loaded onto the Apt–hybr–TCL-SPION through the intercalation of Dox to the CG-rich duplex containing prostate-specific membrane antigen aptamer as well as electrostatic interaction between the Dox-and-polymer coating layer of the nanoparticles, the resulting Dox@Apt–hybr–TCL-SPION showed selective drug-delivery efficacy in the LNCaP xenograft mouse model. [Small] 2′-5′ Oligoadenylate Synthetase 1 Polymorphism Is Associated with Prostate Cancer In this study, the authors investigated the association of the functional 2′-5′ oligoadenylate synthetase polymorphism (rs2660) with prostate cancer. [Cancer] ARFGAP3, an Androgen Target Gene, Promotes Prostate Cancer Cell Proliferation and Migration In the present study, scientists examined the contribution of ADP ribosylation factor GTPase-activating protein 3 (ARFGAP3) to prostate cancer cell biology. [Int J Cancer] Diabetes Causes Multiple Genetic Alterations and Downregulates Expression of DNA Repair Genes in the Prostate In this study, researchers performed a whole-genome cDNA microarray analysis using a streptozotocin-induced diabetic rat model to identify the effects of diabetes on the gene expression profiles in prostate. [Lab Invest] Endoplasmic Reticulum Stress Drives Lipocalin 2 Upregulation in Prostate Cancer Cells in an NF-Kappa B-Dependent Manner Investigators hypothesized that the tumor cell unfolded protein response process regulates Lipocalin 2 production. [BMC Cancer] Troglitazone Suppresses c-Myc Levels in Human Prostate Cancer Cells Via a Peroxisome Proliferator Activated Receptor Gamma-Independent Mechanism To understand the signaling pathways involved in troglitazone-induced decreases in prostate cancer growth, investigators examined the effect of troglitazone on androgen-independent C4-2 human prostate cancer cells. [Cancer Biol Ther] Epidermal Growth Factor Increases Leukemia/Lymphoma Related Factor/POK Erythroid Myeloid Ontogenic Factor (LRF/Pokemon) Expression in Human Prostate Cancer Cells The aim of this study was to examine the regulation of LRF expression in human prostate cells. [Exp Mol Pathol] CLINICAL RESEARCH The CAPRA-S Score: A Straightforward Tool for Improved Prediction of Outcomes After Radical Prostatectomy The Cancer of the Prostate Risk Assessment Score (CAPRA-S) offers good discriminatory accuracy, calibration, and ease of calculation for clinical and research settings. [Cancer] Preoperative Serum Levels of Early Prostate Cancer Antigen (EPCA) Predict Prostate Cancer Progression in Patients Undergoing Radical Prostatectomy The goals of this study were to measure preoperative serum EPCA levels in a cohort of prostate cancer patients who were treated with radical prostatectomy, and to investigate whether serum EPCA levels would independently predict cancer prognosis after the surgery. [Prostate] |