LABORATORY RESEARCH Identification of Stromally Expressed Molecules in the Prostate by Tag-Profiling of Cancer-Associated Fibroblasts, Normal Fibroblasts and Fetal Prostate Researchers have applied next-generation Tag profiling to fetal human prostate, normal human prostate fibroblasts and cancer-associated fibroblasts to identify molecules expressed in prostatic stroma. [Oncogene] Resistance to CYP17A1 Inhibition with Abiraterone in Castration Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants Researchers treated human castration-resistant prostate cancer xenografts with abiraterone and measured tumor growth, tissue androgens, androgen receptor levels, and steroidogenic gene expression vs. controls. [Clin Cancer Res] Anti-Cancer Effects of Novel Flavonoid Vicenin-2 as a Single Agent and in Synergistic Combination with Docetaxel in Prostate Cancer The present study was conducted to determine the efficacy of novel flavonoid vicenin-2, an active constituent of the medicinal herb Ocimum Sanctum Linn or Tulsi, as a single agent and in combination with docetaxel in carcinoma of prostate. [Biochem Pharmacol] Sonoporation Delivery of Interleukin 27 Gene Therapy Efficiently Reduces Prostate Tumor Cell Growth In Vivo In the present study, researchers examined the efficacy of a new mode of gene delivery to prostate tumors, low-frequency ultrasound irradiation or ‘sonoporation’. [Hum Gene Ther] Urine TMPRSS2:ERG Fusion Transcript Stratifies Prostate Cancer Risk in Men with Elevated Serum Prostate-Specific Antigen In this study, researchers report a clinical-grade, transcription-mediated amplification assay to risk stratify and detect prostate cancer noninvasively in urine. [Sci Transl Med] Castration Resistant Prostate Cancer is Associated with Increased Blood Vessel Stabilization and Elevated Levels of VEGF and Ang-2 This study was performed to investigate blood vessel stabilization and expression of the pro-angiogenic factors vascular endothelial growth factor (VEGF) and Angiopoietin-2 (Ang-2) in castration resistant and hormone naïve prostate cancer. [Prostate] The H6D Variant of NAG-1/GDF15 Inhibits Prostate Xenograft Growth In Vivo The objective of the current study is to investigate the activity of non-steroidal anti-inflammatory drug-activated gene (NAG-1) histidine to aspartic acid substitution (H6D) variant in prostate cancer tumorigenesis in vivo. [Prostate] Prostate Carcinoma Cells LNCaP and Glucan Cooperate in Induction of Cytokine Synthesis by Dendritic Cells: Effect on Natural Killer Cells and CD4+ Lymphocytes Activation In this study, researchers investigated the effects of glucan on immune cell response to prostate carcinoma. [Prostate] NMD and MicroRNA Expression Profiling of the Hereditary Prostate Cancer X-Linked 1 Locus Reveal MAGEC1 as a Candidate Prostate Cancer Predisposition Gene In this study, nonsense-mediated mRNA decay (NMD) inhibition was used for the discovery of truncating mutations. [BMC Cancer] Heterogeneous Induction of Carcinoma-Associated Fibroblast-Like Differentiation in Normal Human Prostatic Fibroblasts by Co-Culturing with Prostate Cancer Cells To understand how carcinoma-associated fibroblasts are generated during primary cancer progression, researchers investigated the biochemical characteristics of normal human prostate stromal cells co-cultured with human prostate cancer cells in vitro. [J Cell Biochem] CLINICAL RESEARCH Outcomes and Complications After 532 nm Laser Prostatectomy in Anticoagulated Patients With Benign Prostatic Hyperplasia Researchers explored outcomes and complications after photoselective vaporization of the prostate in an anticoagulated, high risk cohort. [J Urol] Randomised Clinical Trial: Preventive Treatment with Topical Rectal Beclomethasone Dipropionate Reduces Post-Radiation Risk of Bleeding in Patients Irradiated for Prostate Cancer The aim of this study was to assess the effect of topical beclomethasone dipropionate in the prevention of radiation-induced proctopathy in patients undergoing radiotherapy for prostate cancer through a double-blind, placebo-controlled, randomised trial. [Aliment Pharmacol Ther] Associations of Serum Vitamin A and Carotenoid Levels with Markers of Prostate Cancer Detection among US Men Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection were evaluated among 3,927 US men, 40-85 years of age, who participated in the 2001-2006 National Health and Nutrition Examination Surveys. [Cancer Causes Control] Clinicopathological Predictors of Systemic Progression and Prostate Cancer Mortality in Patients with a Positive Surgical Margin at Radical Prostatectomy Researchers evaluated long-term outcomes of patients with a positive surgical margin at radical prostatectomy and determined predictors of systemic progression and mortality in these men. [Prostate Cancer Prostatic Dis] |